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TRAIL

TRAIL Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
TRL-H5259 Human Human TRAIL / TNFRSF10 Protein, Mouse IgG2a Fc Tag
TRL-H5259-structure
TRL-H5259-sds
TRL-H5259-elisa_1

TRAIL Part of Bioactivity data

TRL-H5259-ELISA
Human TRAIL, Mouse IgG2a Fc TagHuman TRAIL, Mouse IgG2a Fc Tag (Cat. No. TRL-H5259) ELISA bioactivity

Immobilized Human Osteoprotegerin, His Tag (Cat. No. TNB-H5220) at 5 μg/mL (100 μL/well) can bind Human TRAIL, Mouse IgG2a Fc Tag (Cat. No. TRL-H5259) with a linear range of 0.8-13 ng/mL (QC tested).

TRAIL Molecule Synonym Name

Apo-2L,TRAIL,CD253,TNFSF10,Apo-2 ligand

TRAIL Molecule Background

TRAIL, also known as  TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.

TRAIL References

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