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CD23

Brief Information

Name:Immunoglobulin epsilon Fc receptor
Target Synonym:C-Type Lectin Domain Family 4, Member J,Immunoglobulin Epsilon-Chain,CD23,Low affinity immunoglobulin epsilon Fc receptor,FCE2,CD23A,FCER2,CLEC4J,BLAST-2,Fc Fragment Of IgE Receptor II,Lymphocyte IgE Receptor,Fc Epsilon Receptor II,Fc-Epsilon-RII,CD23 Ant
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

CD3-H5249-MALS-HPLC
Human CD23, His Tag (Cat. No. ) MALS images

The purity of Human CD23, His Tag (Cat. No. CD3-H5249) was more than 90% and the molecular weight of this protein is around 32-48 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human CD23, His,AvitagBiotinylated Human CD23, His,Avitag (Cat. No. CD3-H82Q5) ELISA bioactivity

Immobilized Immunoglobulin E, Human Plasma at 5 μg/mL (100 μL/well) can bind Biotinylated Human CD23, His,Avitag (Cat. No. CD3-H82Q5) with a linear range of 0.156-2.5 μg/mL (QC tested).

Synonym Name

FCER2,CD23,CD23A,CLEC4J,FCE2,IGEBF,Fc¦ÅRII,Fc¦ÅR¢ò

Background

Cluster of differentiation 23 (CD23) is also known as Low affinity immunoglobulin epsilon Fc receptor (FCER2), C-type lectin domain family 4 member J (CLEC4J), Fc-epsilon-RII (Fc¦ÅRII), Immunoglobulin E-binding factor (IGEBF), is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. CD23 is known to have role of transportation in antibody feedback regulation. Antigen that enters the blood stream is captured by antigen specific IgE antibodies. The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response. In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative).

Clinical and Translational Updates

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