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Your Position: Home > IL-21

IL-21

Brief Information

Name:Interleukin-21
Target Synonym:Za11,IL-21,CVID11,Interleukin-21 Isoform,Interleukin 21
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

IL1-H5253-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-21, Fc Tag (Cat. No. IL1-H5253) stimulates secretion of IFN-gamma by NK-92 human natural killer lymphoma cells. The EC50 for this effect is 0.94-1.34 μg/mL (Routinely tested).

IL1-H5213-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-21, Tag Free (Cat. No. IL1-H5213) immobilized on CM5 Chip can bind Human IL-21 R, Fc Tag (Cat. No. ILR-H5257) with an affinity constant of 0.412 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL1-H82F7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-21, Fc,Avita (Cat. No. IL1-H82F7) immobilized on CM5 Chip can bind Human IL-21 R, Fc Tag (Cat. No. ILR-H5257) with an affinity constant of 0.165 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

IL21,Za11,Interleukin-21

Background

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells.  IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NN-9828 NN-8828; NN-9828; Anti-IL21; NNC114-0005; NNC0114-0006; NNC-0114-0000-0005 Phase 1 Clinical Bristol-Myers Squibb Company Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Inflammation; Crohn Disease; Diabetes Mellitus Details
IL-21 mab (Lilly) Phase 1 Clinical Eli Lilly And Company Immune System Diseases Details
Avizakimab BOS-161721 Phase 2 Clinical Medimmune, Boston Pharmaceuticals Autoimmune Diseases; Lupus Erythematosus, Systemic Details
BNZ-2 BNZ-2 Phase 1 Clinical Bioniz Celiac Disease Details

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