There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > IL-21


IL-21 Molecule Information

Target Synonym:Za11,IL-21,Interleukin 21,Interleukin-21 Isoform,CVID11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

IL-21 Protein Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
Cat. No. Species Product Description Structure Purity Feature
IL1-H5213 Human Human IL-21 Protein, Tag Free, low endotoxin (HPLC verified)
IL1-H5253 Human Human IL-21 Protein, Fc Tag
IL1-H82F7 Human Biotinylated Human IL-21 Protein, Fc,Avitag™ (MALS verified)

IL-21 Part of Bioactivity data

IL1-H5253-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human IL-21, Fc Tag (Cat. No. IL1-H5253) stimulates secretion of IFN-gamma by NK-92 human natural killer lymphoma cells. The EC50 for this effect is 0.94-1.34 μg/mL (Routinely tested).

Human IL-21, Fc TagHuman IL-21, Fc Tag (Cat. No. IL1-H5253) ELISA bioactivity

Immobilized Human IL-21 R, His Tag (Cat. No. ILR-H5226) at 2 μg/mL (100 μL/well) can bind Human IL-21, Fc Tag (Cat. No. IL1-H5253) with a linear range of 0.2-8 ng/mL (QC tested).

Biotinylated Human IL-21, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human IL-21, Fc,Avitag (Cat. No. IL1-H82F7) was more than 85% and the molecular weight of this protein is around 110-130 kDa verified by SEC-MALS.

Biotinylated Human IL-21, Fc,AvitagBiotinylated Human IL-21, Fc,Avitag (Cat. No. IL1-H82F7) ELISA bioactivity

Immobilized Human IL-21 R, Fc Tag (Cat. No. ILR-H5257) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-21, Fc,Avitag (Cat. No. IL1-H82F7) with a linear range of 0.4-6 ng/mL (QC tested).

IL-21 Molecule Synonym Name


IL-21 Molecule Background

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells.  IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

IL-21 References

IL-21 Related Molecule

IL-21 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IL-21 mab (Lilly) Phase 1 Clinical Eli Lilly And Company Immune System Diseases Details
BOS-161721 BOS-161721 Phase 2 Clinical Medimmune, Boston Pharmaceuticals Autoimmune Diseases; Lupus Erythematosus, Systemic Details
NN-9828 NN-8828; NN-9828; Anti-IL21; NNC114-0005; NNC0114-0006; NNC-0114-0000-0005 Phase 1 Clinical Bristol-Myers Squibb Company Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Inflammation; Crohn Disease; Diabetes Mellitus Details

This web search service is supported by Google Inc.