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Your Position: Home > IL-21

IL-21

Brief Information

Name:Interleukin-21
Target Synonym:Za11,IL-21,CVID11,Interleukin-21 Isoform,Interleukin 21
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IL1-H5113 Human Human IL-21 Superior Stable Mutant Protein, premium grade
IL1-H5113-sds
IL1-H5113-hplc
GMP-L21H15 Human GMP Human IL-21 Protein (E. coli)
GMP-L21H15-structure
GMP-L21H15-sds
IL1-H5114 Human Human IL-21 Protein (E. coli), premium grade
IL1-H5114-structure
IL1-H5114-sds
IL1-H5114-hplc
GMP-L21H25 Human GMP Human IL-21 Protein
GMP-L21H25-structure
GMP-L21H25-sds
IL1-M52H3 Mouse Mouse IL-21 Protein, His Tag
IL1-M52H3-structure
IL1-M52H3-sds
CRS-A010 Human resDetect™ Human Interleukin-21 (IL-21) ELISA Kit (Residue Testing)
IL1-C52H9 Cynomolgus Cynomolgus IL-21 Protein, His Tag
IL1-C52H9-structure
IL1-C52H9-sds
IL1-H5213 Human Human IL-21 Protein, premium grade
IL1-H5213-structure
IL1-H5213-sds
IL1-H5213-hplc
IL1-H5253 Human Human IL-21 Protein, Fc Tag
IL1-H5253-structure
IL1-H5253-sds
IL1-H82F7 Human Biotinylated Human IL-21 Protein, Fc,Avitag™, premium grade
IL1-H82F7-structure
IL1-H82F7-sds
ACRO Quality

Part of Bioactivity data

GMP-L21H15-Cell-based assay
IL-21 CELL

GMP Human IL-21 Protein (E. coli) (Cat. No. GMP-L21H15) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells stimulated with GMP Human IL-15 Protein (Cat. No. GMP-L15H13). The specific activity of GMP Human IL-21 Protein (E. coli) is > 1.00 x 10^5 U/mg (QC tested).

Protocol
IL1-H5114-Cell-based assay
IL-21 CELL

Human IL-21 Protein (E. coli), premium grade (Cat. No. IL1-H5114) stimulates secretion of IFN-γ by NK-92 human natural killer lymphoma cells stimulated with GMP Human IL-15 Protein (Cat. No. GMP-L15H13). The specific activity of Human IL-21 Protein (E. coli), premium grade is > 1.00 × 10^5 U/mg (QC tested).

Protocol
IL1-H82F7-SPR
IL-21 SPR

Biotinylated Human IL-21, Fc,Avitag, premium grade (Cat. No. IL1-H82F7) immobilized on CM5 Chip can bind Human IL-21 R, Fc Tag (Cat. No. ILR-H5257) with an affinity constant of 0.165 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
IL1-M52H3-ELISA
IL-21 ELISA

Immobilized Mouse IL-21 Protein, His Tag (Cat. No. IL1-M52H3) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-21 R Protein, His,Avitag (Cat. No. ILR-M82E3) with a linear range of 0.3-20 ng/mL (QC tested).

Protocol

Synonym Name

IL21,Za11,Interleukin-21

Background

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells.  IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

Clinical and Translational Updates

Related Molecule

IL-21 R

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Avizakimab BOS-161721 Phase 2 Clinical Medimmune, Boston Pharmaceuticals Inc Lupus Erythematosus, Systemic Details
hV-01 hV-01 Phase 2 Clinical Hangzhou Converd Co Ltd Sarcoma 180; Solid tumours; Uterine Cervical Neoplasms Details
IL-21 mab (Lilly) Phase 1 Clinical Eli Lilly And Company Immune System Diseases Details

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