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Your Position: Home > IgG3 Fc

IgG3 Fc

Brief Information

Name:Immunoglobulin G
Target Synonym:Immunoglobulin G
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Part of Bioactivity data

IG3-H5200-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) captured on CM5 Chip via anti-His antibody can bind Human IgG3 Fc, Tag Free (Cat. No. IG3-H5200) with an affinity constant of 2.82 μM as determined in SPR assay (Biacore 8K) (QC tested).

IG3-MY2179-ELISA
 IgG3 Fc ELISA

Immobilized Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG3 (AS35) (Cat. No. SPD-S67) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IgG3 Fc Antibody, Mouse IgG2a (2B7) (Cat. No. IG3-MY2179) with a linear range of 0.1-2 ng/mL (QC tested).

Synonym Name

Ig gamma-3 chain C region,IgG, IgG3

Background

Immunoglobulin G3 (IgG3) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. Ig gamma-3 chain C region (IgG3-Fc / IGHG3) contains two constant regions of IgG3 H chain (CH2, CH3).

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Imlifidase Mac-1 Approved Hansamed Inc Idefirix EU Rejection of renal transplantation Hansa Biopharma Ab 2020-08-25 Rejection of renal transplantation; Kidney Diseases; Purpura, Thrombotic Thrombocytopenic; Rejection of organ transplantation; Renal Insufficiency, Chronic; Guillain-Barre Syndrome; Kidney Failure, Chronic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ricefidase KJ-103; KJ103 Phase 3 Clinical Shanghai Bao Pharmaceuticals Co Ltd Rejection of renal transplantation; Anti-Glomerular Basement Membrane Disease Details
AT-02 AT-02 Phase 2 Clinical Attralus Inc Immunoglobulin Light-chain Amyloidosis; Amyloidosis Details
BHV-1300 BHV-1300 Phase 1 Clinical Biohaven Pharmaceuticals Inc Arthritis, Rheumatoid Details
HNSA-5487 HNSA 5487; HNSA-5487 Phase 1 Clinical Hansa Biopharma Ab Neoplasms; Autoimmune Diseases Details
Anti-CD33/anti-FcgammaRI bispecific antibody (UCSD) Phase 1 Clinical University Of California San Diego Leukemia, Myeloid, Acute Details

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