IgG2 Fc Protein - ACROBiosystems

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IgG2 Fc


IG2-H5206	Human	Human IgG2 Fc Protein, Tag Free (MALS & SPR verified)

Cat. No.

Species

Product Description

Structure

Purity

Feature

IG2-H5206

Human

Human IgG2 Fc Protein, Tag Free (MALS & SPR verified)

Part of Bioactivity data

IG2-H5206-MALS-HPLC

Human FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCN-H52W7) captured on CM5 Chip via anti-His antibody can bind Human IgG2 Fc, Tag Free (Cat. No. IG2-H5206) with an affinity constant of 33.3 nM as determined in SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

IGHG2

Background

Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-? (IgG) antibody molecules changes in rheumatoid arthritis. Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).

Clinical and Translational Updates