Name:Scavenger receptor cysteine-rich type 1 protein M130 Target Synonym:CD163,M130,Scavenger receptor cysteine-rich type 1 protein M130,sCD163,CD163 Molecule,Hemoglobin Scavenger Receptor,CD163 Antigen,Macrophage-Associated Antigen,SCARI1,MM130
Number of Launched Drugs:1 Number of Drugs in Clinical Trials:0 Lastest Research Phase:Approved
Scavenger receptor cysteine-rich type 1 protein M130 (CD163) is also known as hemoglobin scavenger receptor, which is a scavenger receptor for the hemoglobin-haptoglobin complex. CD163 has also been shown to mark cells of monocyte/macrophage lineage. A soluble form of the receptor exists in plasma, commonly denoted sCD163. sCD163 is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, macrophage activation syndrome, Gaucher's disease, sepsis, HIV infection, rheumatoid arthritis and Hodgkin Lymphoma.