0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > MAG / Siglec-4a

MAG / Siglec-4a

MAG / Siglec-4a Protein Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
MAG-H5254 Human Human MAG / Siglec-4a Protein, Fc Tag
MAG-H5254-structure
MAG-H5254-sds
MAG-H52H8 Human Human MAG / Siglec-4a Protein, His Tag
MAG-H52H8-structure
MAG-H52H8-sds

MAG / Siglec-4a Molecule Synonym Name

MAG,Siglec-4a,GMA,S-MAG

MAG / Siglec-4a Molecule Background

Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2.  Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2.  In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.

MAG / Siglec-4a References

This web search service is supported by Google Inc.

totop