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Your Position: Home > P-Selectin

P-Selectin

Brief Information

Name:P-selectin
Target Synonym:Platelet Activation Dependent Granule-External Membrane Protein,Granule Membrane Protein 140kDa,PADGEM,GRMP,Selectin P (Granule Membrane Protein 140kD, Antigen CD62),Platelet Alpha-Granule Membrane Protein,Granulocyte Membrane Protein,CD62P Antigen,Antigen CD62,P-Selectin,GMP140,CD62P,CD62,PSEL,LECAM3,CD62 antigen-like family member P,GMRP,GMP-140,Granule membrane protein 140,SELP,Selectin P,Selectin P (Granule Membrane Protein 140kDa, Antigen CD62),Leukocyte-Endothelial Cell Adhesion Molecule 3
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
SEP-H5255 Human Human P-Selectin / CD62P Protein, Fc Tag
SEP-H5255-structure
SEP-H5255-sds
SEP-H52E4 Human Human P-Selectin / CD62P Protein, His Tag
SEP-H52E4-structure
SEP-H52E4-sds

Synonym Name

P-Selectin,CD62P,SELP,GMP-140

Background

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in ¦Á-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Crizanlizumab Sel-G-1; SEG-101; Sel-G1 Approved Novartis Pharma Ag, Selexys Adakveo EU Anemia, Sickle Cell Novartis Europharm Ltd 2019-11-15 Coronavirus Disease 2019 (COVID-19); Leukoencephalopathies; Priapism; Primary Myelofibrosis; Anemia, Sickle Cell Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Dociparstat sodium ODSH; CX-01; PGX-100; PGX-ODSH-2013-AML-1 Paringenix Details
Inclacumab RG-1512; RO-4905417; LC-1004-002; DSM-ACC-2641; R-1512 Phase 3 Clinical F. Hoffmann-La Roche Ltd, Genmab Myocardial Infarction; Pain; Graft Occlusion, Vascular; Peripheral Arterial Disease; Anemia, Sickle Cell Details

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