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P-Selectin Molecule Information

Target Synonym:GMRP ;Leukocyte-endothelial cell adhesion molecule 3;CD_antigen=CD62P;GMP-140;SELP;LECAM3;Granule membrane protein 140;P-selectin;CD62 antigen-like family member P;PADGEM;Platelet activation dependent granule-external membrane protein;GRMP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:BLA ??

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Cat. No. Species Product Description Structure Purity Feature
SEP-H5255 Human Human P-Selectin / CD62P Protein, Fc Tag
SEP-H52E4 Human Human P-Selectin / CD62P Protein, His Tag

P-Selectin Molecule Synonym Name


P-Selectin Molecule Background

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in ¦Á-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

P-Selectin References

P-Selectin Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Crizanlizumab-tmca SEG-101; Sel-G1; Sel-G-1,SelG1 Approved Selexys, Novartis ADAKVEO fda NOVARTIS PHARMS CORP 2019-11-15 Sickle cell disease Details

P-Selectin Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bimosiamose TBC-1269 Phase Ⅱ Encysive, Revotar Plaque psoriasis, Atopic dermatitis, Chronic obstructive pulmonary disease (COPD), Asthma Details
Torapsel YSPSL Phase Ⅱ Pfizer, Ys Therapeutics Reperfusion injury, Myocardial infarction (MI), Delayed graft function Details
Inclacumab LC-1004-002; R-1512; RG-1512; DSM-ACC-2641; RO-4905417 Phase Ⅱ Genmab, Roche, Global Blood Therapeutics Acute coronary syndrome (ACS), Peripheral vascular disorders, Myocardial infarction (MI) Details
Dociparstat sodium CX-01; ODSH; PGX-100; PGX-ODSH-2013-AML-1 Phase Ⅲ ParinGenix, Cantex, Chimerix Coronavirus Disease 2019 (COVID-19) Details
CY-1503 CY-1503 Phase Ⅲ Epimmune Inc., Sumitomo Dainippon Reperfusion injury, Respiratory-tract disorders Details
Rivipansel Sodium GM-1070; GMI-1070; PF-06460031-02; PF-06460031 (free base); PF-6460031 ,GMI1070,PF0646003102 Phase Ⅲ GlycoMimetics Pharmaceutical, Pfizer Sickle cell vaso-occlusive crisis Details
Monoclonal antibody EP-5C7  (PDL BioPharma) EP-5C7 Phase Ⅰ PDL BioPharma Stroke, Autoimmune diseases, Psoriasis, Shock, Asthma Details

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