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Your Position: Home > CX3CL1

CX3CL1

Brief Information

Name:C-X3-C motif chemokine ligand 1
Target Synonym:Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member 1 (Fractalkine, Neurotactin),Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member-1,CX3CL1,Small-inducible cytokine D1,FKN,Fractalkine,A-152E5.2,C-X3-C Motif Chemokine Ligand 1,Chemokine (C-X3-C Motif) Ligand 1,CX3C Membrane-Anchored Chemokine,C-X3-C Motif Chemokine 1,Neurotactin,SCYD1,NTT,C3Xkine,ABCD-3,CXC3C,CXC3,NTN,Chemokine CX3CL1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Synonym Name

CX3CL1,Fractalkine

Background

Fractalkine (CX3CL1), a member of the intercrine delta family, is also known as C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, neurotactin and small-inducible cytokine D1, which can be cleaved into processed fractalkine. The soluble form of CX3XL1 is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. CX3CL1 may also play a role in regulating leukocyte adhesion and migration processes at the endothelium. Furthermore, CX3CL1 can bind to CX3CR1.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Quetmolimab E-6011; KANAB-001 Phase 2 Clinical Eisai Co Ltd Liver Cirrhosis, Biliary; Arthritis, Rheumatoid; Crohn Disease Details

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