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Your Position: Home > CX3CL1

CX3CL1

Brief Information

Name:C-X3-C motif chemokine ligand 1
Target Synonym:Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member 1 (Fractalkine, Neurotactin),Small Inducible Cytokine Subfamily D (Cys-X3-Cys), Member-1,CX3CL1,Small-inducible cytokine D1,FKN,Fractalkine,A-152E5.2,C-X3-C Motif Chemokine Ligand 1,Chemokine (C-X3-C Motif) Ligand 1,CX3C Membrane-Anchored Chemokine,C-X3-C Motif Chemokine 1,Neurotactin,SCYD1,NTT,C3Xkine,ABCD-3,CXC3C,CXC3,NTN,Chemokine CX3CL1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CX1-C5222 Cynomolgus Cynomolgus CX3CL1 / Fractalkine Protein, His Tag (MALS verified)
CX1-C5222-structure
CX1-C5222-sds
CX1-H5221 Human Human CX3CL1 / Fractalkine Protein, His Tag
CX1-H5221-structure
CX1-H5221-sds
CX1-H8221 Human Biotinylated Human CX3CL1 Protein, His Tag, ultra sensitivity, primary amine labeling
CX1-H8221-structure
CX1-H8221-sds
ACRO Quality

Part of Bioactivity data

CX1-C5222-ELISA
CX3CL1 MALS images

The purity of Cynomolgus CX3CL1 Protein, His Tag (Cat. No. CX1-C5222) is more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Synonym Name

CX3CL1,Fractalkine

Background

Fractalkine is also known as C-X3-C motif chemokine 1 (CX3CL1) and neurotactin. Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is found commonly throughout the brain, particularly in neural cells, and its receptor is known to be present on microglial cells. It has also been found to be essential for microglial cell migration. CX3CL1 is also up-regulated in the hippocampus during a brief temporal window following spatial learning, the purpose of which may be to regulate glutamate-mediated neurotransmission tone. This indicates a possible role for the chemokine in the protective plasticity process of synaptic scaling.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Quetmolimab E-6011; KANAB-001 Phase 2 Clinical Eisai Co Ltd Liver Cirrhosis, Biliary; Arthritis, Rheumatoid; Crohn Disease Details

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