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B7-H6

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Part of Bioactivity data

B76-H82E5-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human B7-H6, His,Avitag (Cat. No. B76-H82E5) immobilized on SA Chip can bind Human NKp30, His Tag (Cat. No. NC3-H5228) with an affinity constant of 0.213 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

B76-C52Ha-ELISA
Cynomolgus B7-H6Cynomolgus B7-H6 (Cat. No. B76-C52Ha) ELISA bioactivity

Immobilized Human NKp30, Fc Tag (Cat. No. NC3-H5259) at 5 μg/mL (100 μL/well) can bind Cynomolgus B7-H6 (Cat. No. B76-C52Ha) with a linear range of 0.625-5 μg/mL (QC tested).

Synonym Name

B7-H6,NCR3LG1,B7 Homolog 6

Background

The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.

Clinical and Translational Updates

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