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CBLB

Brief Information

Name:E3 ubiquitin-protein ligase CBL-B
Target Synonym:Casitas B-lineage lymphoma proto-oncogene b,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,RING finger protein 56,Signal transduction protein CBL-B,Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B,Cbl Proto-Oncogene, E3 Ub
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CBB-H5148 Human Human CBLB / RNF56 Protein, His Tag
CBB-H5148-structure
CBB-H5148-sds
CBB-H81Q8 Human Biotinylated Human CBLB / RNF56 Protein, His,Avitag™
CBB-H81Q8-structure
CBB-H81Q8-sds

Synonym Name

CBL-B,CBLB,RNF56

Background

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
APN-401 APN-401 Phase 2 Clinical Apeiron Biologics Neoplasms Details

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