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Your Position: Home > CBLB

CBLB

Brief Information

Name:E3 ubiquitin-protein ligase CBL-B
Target Synonym:Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B,Casitas B-lineage lymphoma proto-oncogene b,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,RING finger protein 56,Nbla00127,RNF56,Signal transduction protein CBL-B,Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B,Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase B,Cbl Proto-Oncogene B,Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase,Cbl-B
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CBB-H5148 Human Human CBLB / RNF56 Protein, His Tag
CBB-H5148-structure
CBB-H5148-sds
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Synonym Name

CBL-B,CBLB,RNF56

Background

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HST-1011 HST-1011; HST1011 Phase 2 Clinical HotSpot Therapeutics Inc Solid tumours; Neoplasms Details
APN-401 APN-401 Phase 1 Clinical Apeiron Biologics Solid tumours; Carcinoma, Renal Cell; Pancreatic Neoplasms; Colorectal Neoplasms; Brain metastases; Melanoma; Neoplasm Metastasis Details
NX-1607 NX-1607 Phase 1 Clinical Nurix Therapeutics Inc Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Mesothelioma; Richter's Syndrome; Colorectal Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details

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