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Your Position: Home > Prolactin R

Prolactin R

Brief Information

Name:Prolactin receptor
Target Synonym:PRL-R,PRLR,Prolactin Receptor,Secreted Prolactin Binding Protein,HPRL Receptor,RI-PRLR,HPRLrI,HPRL,MFAB,Receptors, Prolactin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
PRR-H52Ha Human Human Prolactin R / PRLR Protein, His Tag
PRR-H52Ha-structure
PRR-H52Ha-sds
PRP-H5251 Human Human Prolactin R / PRLR Protein, Fc Tag
PRP-H5251-structure
PRP-H5251-sds
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Part of Bioactivity data

PRP-H5251-ELISA
Human Prolactin R, Fc TagHuman Prolactin R, Fc Tag (Cat. No. PRP-H5251) ELISA bioactivity

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. PRN-H5257) at 1 μg/mL (100 μL/well) can bind Human Prolactin R, Fc Tag (Cat. No. PRP-H5251) with a linear range of 2-39 ng/mL (QC tested).

Protocol
PRR-H52Ha-ELISA
Human Prolactin R, His TagHuman Prolactin R, His Tag (Cat. No. PRR-H52Ha) ELISA bioactivity

Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. PRN-H5257) at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. PRR-H52Ha) with a linear range of 20-156 ng/mL (QC tested).

Protocol

Synonym Name

Prolactin R, PRLR, PRL-R

Background

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BAY-1158061 BAY-1158061; HMI-115 Phase 2 Clinical Bayer AG Alopecia; Pain; Endometriosis Details

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