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Your Position: Home > Fc gamma RIII / CD16

Fc gamma RIII / CD16

Fc gamma RIII / CD16 Part of Bioactivity data

FC6-R52H6-SPR

Rhesus macaque CD16, His Tag (Cat. No. FC6-R52H6) captured on CM5 Chip via anti-His antibody can bind Rituximab with an affinity constant of 0.232 μM as determined in SPR assay (Biacore T200) (QC tested).

Protocol

FC6-C82E0-SPR

Captured Biotinylated Cynomolgus CD16, His,Avitag (BLI verified) (Cat. No. FC6-C82E0) on Biotin CAP - Series S sensor Chip can bind MabThera® (Rituximab) with an affinity constant of 0.63 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Fc gamma RIII / CD16 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
FC6-R52H6	Rhesus macaque	Rhesus macaque Fc gamma RIII / CD16 Protein, His Tag (SPR & BLI verified)
FC6-C82E0	Cynomolgus	Biotinylated Cynomolgus Fc gamma RIII / CD16 Protein, His,Avitag™ (BLI verified)
FC6-C52H9	Cynomolgus	Cynomolgus Fc gamma RIII / CD16 Protein, His Tag (BLI verified)
CDA-M52H8	Mouse	Mouse Fc gamma RIII / CD16 Protein, His Tag (SPR & BLI verified)

Fc gamma RIII / CD16 Molecule Synonym Name

FCGR3

Fc gamma RIII / CD16 Molecule Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors Fc?RIIIa (CD16a) and Fc?RIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.