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Your Position: Home > Galectin-9

Galectin-9

Brief Information

Name:Galactoside-binding lectin Galectin 9
Target Synonym:Ecalectin,Tumor antigen HOM-HD-21,Galectin-9,Lectin, Galactoside-Binding, Soluble, 9,LGALS9
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

LG9-H82H3-SPR
 Galectin-9 SPR

Human TIM-3 (22-200) Protein, Fc Tag (Cat. No. TM3-H5258) immobilized on CM5 Chip can bind Biotinylated Human Galectin-9, His,Avitag (Cat. No. LG9-H82H3) with an affinity constant of 7.66 μM as determined in a SPR assay (Biacore 8K) (QC tested).

LG9-H5244-SPR
 Galectin-9 SPR

Human TIM-3 (22-200) Protein, Fc Tag (Cat. No. TM3-H5258) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Galectin-9, His Tag (Cat. No. LG9-H5244) with an affinity constant of 57 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Galectin-9,LGALS9,Ecalectin

Background

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LYT-200 LYT-200 Phase 2 Clinical Puretech Solid tumours; Head and Neck Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Cholangiocarcinoma; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Neoplasm Metastasis Details

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