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Galectin-9

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Cat. No. Species Product Description Structure Purity Feature
LG9-H5123 Human Human Galectin-9 / LGALS9 Protein, His Tag
LG9-H5123-structure
LG9-H5244 Human Human Galectin-9 / LGALS9 Protein, His Tag
LG9-H5244-structure
LG9-H5244-sds
LG9-H5244-elisa_2

Part of Bioactivity data

LG9-H5244-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human TIM-3, Fc Tag (Cat. No. TM3-H5258) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Galectin-9, His Tag (Cat. No. LG9-H5244) with an affinity constant of 57 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Galectin-9,LGALS9,Ecalectin

Background

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

Clinical and Translational Updates

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