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ADAM17 Molecule Information

Name:Disintegrin and metalloproteinase domain-containing protein 17
Target Synonym:CD_antigen=CD156b;TACE;TNF-alpha-converting enzyme;CSVP ;ADAM 17;ADAM17;Snake venom-like protease;Disintegrin and metalloproteinase domain-containing protein 17;TNF-alpha convertase
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
AD7-M52H1 Mouse Mouse ADAM17 / TACE / CD156b Protein, His Tag

ADAM17 Molecule Synonym Name


ADAM17 Molecule Background

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.

ADAM17 References

ADAM17 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Aderbasib INCB-7839; INCB-007839; INC-B007839,INCB007839,INCB7839 Phase Ⅱ Incyte Breast cancer, Solid tumours, Non-Hodgkin's lymphoma (NHL) Details
BMS-561392 BMS-561392; DPC-333,BMS561392,DPC333 Phase Ⅱ Bristol-Myers Squibb Rheumatoid arthritis (RA), Inflammatory bowel disease Details
Apratastat TMI-005,TMI005 Phase Ⅱ Pfizer Rheumatoid arthritis (RA) Details

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