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ADAMTS5

ADAMTS5 Molecule Information

Name:ADAMTS5
Target Synonym:ADAMTS5;ADMP2;A disintegrin and metalloproteinase with thrombospondin motifs 5;ADAM-TS 11;ADAM-TS 5;Aggrecanase-2;ADAM-TS5;ADAMTS-5;ADAMTS-11;ADMP-2;A disintegrin and metalloproteinase with thrombospondin motifs 11;ADAMTS11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

ADAMTS5 Molecule Synonym Name

ADAM-TS 5, ADAM-TS5, ADAMTS-5, ADAM-TS 11, ADAMTS-11, ADMP-2, ADAMTS11, ADMP2, Aggrecanase-2

ADAMTS5 Molecule Background

Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis. ADAMTS levels and activities are regulated at multiple levels through the control of gene expression, mRNA splicing, protein processing and inhibition by TIMP (tissue inhibitor of metalloproteinases). A recent screen of human cartilage has shown that multiple members of the ADAMTS family may be important in connective tissue homeostasis and pathology. ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), also known as aggrecanase-2 and ADAMTS11, is a member of the family of secreted zinc proteases with a multi-domain structure.

ADAMTS5 References

ADAMTS5 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CRB-0017 CRB-0017 Phase Ⅰ Rottapharm Osteoarthritis (OA) Details
GLPG-1972 GLPG-1972; GLPG-1972/S201086; S-201086 Phase Ⅱ Galapagos, Servier Osteoarthritis (OA) Details

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