ADAMTS5 Molecule Information
Target Synonym:ADAMTS5;ADMP2;A disintegrin and metalloproteinase with thrombospondin motifs 5;ADAM-TS 11;ADAM-TS 5;Aggrecanase-2;ADAM-TS5;ADAMTS-5;ADAMTS-11;ADMP-2;A disintegrin and metalloproteinase with thrombospondin motifs 11;ADAMTS11
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?
ADAMTS5 Molecule Synonym Name
ADAM-TS 5, ADAM-TS5, ADAMTS-5, ADAM-TS 11, ADAMTS-11, ADMP-2, ADAMTS11, ADMP2, Aggrecanase-2
ADAMTS5 Molecule Background
Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis. ADAMTS levels and activities are regulated at multiple levels through the control of gene expression, mRNA splicing, protein processing and inhibition by TIMP (tissue inhibitor of metalloproteinases). A recent screen of human cartilage has shown that multiple members of the ADAMTS family may be important in connective tissue homeostasis and pathology. ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), also known as aggrecanase-2 and ADAMTS11, is a member of the family of secreted zinc proteases with a multi-domain structure.
Porter S., et al. 2005, Biochem J. 386(Pt 1), 15-27.
Jones GC., et al. 2005, Arthritis Res Ther., 7(4), 160-9.
Kashiwagi M., et al. 2004, J Biol Chem., 279(11), 10109-19.
ADAMTS5 Clinical Drug Information
||GLPG-1972; GLPG-1972/S201086; S-201086