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Home PageAll MoleculesIntegrin alpha L beta 2
Integrin alpha L beta 2
Integrin alpha L beta 2 Overview
| English Name | Integrin alpha-L/beta-2 (LFA-1) | Approved Drugs | 1 |
| Drugs in Clinical Trials | 1 | Target Synonym | Lymphocyte Function-Associated Antigen-1 |
| Highest Development Stage | Approved | ||
| English Name | Integrin alpha-L/beta-2 (LFA-1) |
| Target Synonym | Lymphocyte Function-Associated Antigen-1 |
| Approved Drugs | 1 |
| Drugs in Clinical Trials | 1 |
| Highest Development Stage | Approved |
Integrin alpha L beta 2 Product List
- Product Category
Protein (1)
- Product Status
Launched (1)
- Species
Human (1)
- Tag
His Tag (1)
- Conjugate
Unconjugated (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
IT2-H53W3 |  Human | CHO | Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free |  |  |  |  Add to Cart |
Total: 1
- 1
Integrin alpha L beta 2 Background
Integrin alpha-L beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha L beta 2 is also a receptor for F11R (By similarity). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin alpha L beta 2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Integrin alpha L beta 2 Synonyms
Integrin alpha L beta 2,ITGAL&ITGB2
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Alintegimod | 7HP349; 7-HP-349; 7HP-349 | Phase 2 Clinical | 7 Hills Pharma LLC | Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Chagas Disease; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Influenza, Human; Kidney Neoplasms; Lymphoma; Melanoma; Mesothelioma; Mismatch Repair Deficient Cancer; Neoplasm Metastasis; Neoplasms; Skin Neoplasms; Solid tumours; Tuberculosis | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Lifitegrast | SHP-606; SAR-1119; SAR-1118; SPD-606; OJL-332 | Approved | Shire Development Llc | Xiidra, 朗悦明 | United States | Dry Eye Syndromes | Bausch And Lomb Inc | 2016-07-11 | Conjunctivitis, Allergic; Diabetic macular oedema; Dry Eye Syndromes; Graft vs Host Disease; Keratoconjunctivitis Sicca; Xerophthalmia | Details |
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