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Your Position: Home > Fc gamma RIIIB / CD16b (NA2)

Fc gamma RIIIB / CD16b (NA2)

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Cat. No. Species Product Description Structure Purity Feature
CDB-H5283 Human Human Fc gamma RIIIB / CD16b (NA2) Protein, Strep Tag (MALS & SPR verified)
CDB-H5283-structure
CDB-H5283-sds
CDB-H5294 Human Human Fc gamma RIIIB / CD16b (NA2) Protein, SUMO,His Tag (MALS & BLI-verified)
CDB-H5294-structure
CDB-H5294-sds
CDB-H82Ea Human Biotinylated Human Fc gamma RIIIB / CD16b (NA2) Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDB-H82Ea-structure
CDB-H82Ea-sds
CDB-H5222 Human Human Fc gamma RIIIB / CD16b (NA2) Protein, His Tag (SPR & BLI & MALS verified)
CDB-H5222-structure
CDB-H5222-sds
ACRO Quality

Part of Bioactivity data

CDB-H5283-SPR
Fc gamma RIIIB / CD16b (NA2) SPR

Human CD16b (NA2) Protein, Strep Tag (Cat. No. CDB-H5283) immobilized on CM5 Chip can bind Rituximab with an affinity constant of 9.05 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
CDB-H5283-SPR
Fc gamma RIIIB / CD16b (NA2) SPR

Rituximab immobilized on CM5 Chip can bind Human CD16b (NA2) Protein, Strep Tag (Cat. No. CDB-H5283) with an affinity constant of 8.18 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

Fc gamma RIIIB,CD16b (NA2),FCGR3B,CD16B,FCG3B,FCGR3,FCG3,IGFR3

Fc gamma RIIIB / CD16b (NA2) ????

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors Fc?RIIIa (CD16a) and Fc?RIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16B is also kown as FCGR3B and FCG3B, is expressed specifically by polymorphonuclear leukocytes (neutrophils) and stimulated eosinophils. CD16B is the low affinity receptor for the Fc region of immunoglobulins gamma. FCGR3B binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, FCG3B is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. CD16B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Fc gamma RIIIB / CD16b (NA2) ????

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