Fc gamma RIIIB / CD16b (NA2) Protein

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Fc gamma RIIIB / CD16b (NA2)


CDB-H5294	Human	Human Fc gamma RIIIB / CD16b (NA2) Protein, SUMO,His Tag (MALS & BLI-verified)
CDB-H82Ea	Human	Biotinylated Human Fc gamma RIIIB / CD16b (NA2) Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDB-H5222	Human	Human Fc gamma RIIIB / CD16b (NA2) Protein, His Tag (SPR & BLI & MALS verified)

Cat. No.

Species

Product Description

Structure

Purity

Feature

CDB-H5294

Human

Human Fc gamma RIIIB / CD16b (NA2) Protein, SUMO,His Tag (MALS & BLI-verified)

CDB-H82Ea

Human

Biotinylated Human Fc gamma RIIIB / CD16b (NA2) Protein, His,Avitag™ (SPR & BLI & MALS verified)

CDB-H5222

Human

Human Fc gamma RIIIB / CD16b (NA2) Protein, His Tag (SPR & BLI & MALS verified)

Part of Bioactivity data

CDB-H82Ea-SPR

Biotinylated Human CD16b (NA2), His,Avitag (Cat. No. CDB-H82Ea) captured on Biotin CAP- Series S Sensor Chip can bind Rituximab with an affinity constant of 4.22 μM as determined in a SPR assay (Biacore T200) (QC tested).

Protocol

CDB-H82Ea-SPR

Immobilized Biotinylated Human CD16b (NA2), His,Avitag (Cat. No. CDB-H82Ea) on SA Chip can bind Rituximab with an affinity constant of 6.66 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

Fc gamma RIIIB,CD16b (NA2),FCGR3B,CD16B,FCG3B,FCGR3,FCG3,IGFR3

Fc gamma RIIIB / CD16b (NA2) ????

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors Fc?RIIIa (CD16a) and Fc?RIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16B is also kown as FCGR3B and FCG3B, is expressed specifically by polymorphonuclear leukocytes (neutrophils) and stimulated eosinophils. CD16B is the low affinity receptor for the Fc region of immunoglobulins gamma. FCGR3B binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, FCG3B is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. CD16B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Fc gamma RIIIB / CD16b (NA2) ????