CD38
CD38 Molecule Information
Name：Lymphocyte differentiation antigen CD38
Target Synonym：2 -phospho-ADP-ribosyl cyclase?T10?CD38?2 -phospho-cyclic-ADP-ribose transferase?CD_antigen=CD38?2 -phospho-ADP-ribosyl cyclase/2 -phospho-cyclic-ADP-ribose transferase?ADPRC 1?Cyclic ADP-ribose hydrolase 1?ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Number of Launched Drugs：1
Number of Drugs in Clinical Trials：9
Lastest Research Phase：Approved
CD38 Molecule Synonym Name
CD38,T10,cADPr hydrolase 1
CD38 Molecule Background
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
CD38 References
CD38 Public Drug Information
| Name |
Research Code |
Research Phase |
Company |
First Brand Name |
First Approved Country |
First Indication |
First Approved Company |
First Approved Date |
Indications |
Clinical Trials |
| Daratumumab |
3003-005; HuMax-CD38; JNJ-54767414; Dara-SC ,HuMaxCD38 |
Approved |
Janssen |
DARZALEX |
fda |
Multiple myeloma (MM) |
JANSSEN BIOTECH |
2015-11-16 |
Multiple myeloma (MM) |
Details
|
CD38 Clinical Drug Information
| Name |
Research Code |
Research Phase |
Company |
Indications |
Clinical Trials |
| GBR-1342 |
GBR-1342 |
Phase Ⅰ |
Glenmark Pharma |
Multiple myeloma (MM) |
Details
|
| Anti-BCMA anti-CD38 bispecific chimeric antigen receptor T cell therapy (Shengyan Pharmaceutical Technology) |
|
Phase Ⅰ |
Wuhan Union Hospital, Shengyan Pharmaceutical Technology |
Multiple myeloma (MM) |
Details
|
| TAK-079 |
TAK-079,TAK079 |
Phase Ⅱ |
Takeda |
Multiple myeloma (MM) |
Details
|
| AMG-424 |
AMG-424 |
Phase Ⅰ |
Xencor, Amgen |
Multiple myeloma (MM) |
Details
|
| Isatuximab |
SAR-650984,SAR650984 |
Phase Ⅲ |
ImmunoGen, Sanofi |
Non small cell lung cancer (NSCLC), Prostate cancer, Plasma cell myeloma, Colorectal cancer, Multiple myeloma (MM), Amyloid light chain amyloidosis (AL amyloidosis) |
Details
|
| TAK-573 |
TAK-573; TEV-48573 |
Phase Ⅱ |
Takeda |
Multiple myeloma (MM) |
Details
|
| FT-500 |
FT-500; FT-516; FT-538; FT-596 |
Preclinical |
Fate therapeutics, University of Minnesota |
Cancer |
Details
|
| Anti CD38 chimeric antigen receptor T-cell therapy (Sorrento Therapeutics) |
|
Phase Ⅰ |
Sorrento Therapeutics, Celularity |
Multiple myeloma (MM) |
Details
|
| MOR-202 |
MOR-202; MOR-03087; TJ-202 |
Phase Ⅱ |
MorphoSys, I-MAB Biopharma |
Multiple myeloma (MM) |
Details
|
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