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Your Position: Home > LAP (TGF-beta 1)

LAP (TGF-beta 1)

Brief Information

Name:Transforming growth factor beta 1
Target Synonym:Latency-Associated Peptide,IBDIMDE,Transforming Growth Factor beta1,Prepro-Transforming Growth Factor Beta-1,TGF-Beta-1,Transforming Growth Factor, Beta 1,CED,TGFB,DPD1,TGFB1,Transforming Growth Factor Beta-1 Proprotein,Camurati-Engelmann Disease,LAP,TGFbeta,Transforming Growth Factor Beta 1,Diaphyseal Dysplasia 1, Progressive,TGF-Beta1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Approved

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Part of Bioactivity data

LAP-H5213-ELISA
 LAP (TGF-beta 1) ELISA

Immobilized Human LAP (TGF-beta 1), Tag Free (Cat. No. LAP-H5213) at 1 μg/mL (100 μL/well) can bind Human ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-H52W4) with a linear range of 5-39 ng/mL (QC tested).

LAP-H82F8-MALS-HPLC
LAP (TGF-beta 1) MALS images

The purity of Biotinylated Human LAP (TGF-beta 1) (C33S), Fc,Avitag (Cat. No. LAP-H82F8) is more than 90% and the molecular weight of this protein is around 129-157 kDa verified by SEC-MALS.

Synonym Name

LAP (TGF-beta 1),LAP (TGFB1),TGFB1,CED,DPD1,LAP,TGF-beta-1,TGFB

Background

Transforming growth factor beta 1 ( TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis.  The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I  and Decorin.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tonogenchoncel-L TG-C Approved Tissuegene Invossa-K, Invossa South Korea Osteoarthritis null 2017-07-01 Intervertebral Disc Degeneration; Osteoarthritis, Knee; Osteoarthritis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Vactosertib TEW-7197; EW-7197; NOV-1301 Phase 3 Clinical Medpacto Inc Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Myeloproliferative Disorders; Osteosarcoma; Colorectal Neoplasms; Urologic Neoplasms; Esophageal adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Adenocarcinoma Details
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C Phase 3 Clinical Merck Serono Brain metastases; Cholangiocarcinoma; Breast Neoplasms; Microsatellite Instability; Vulvar Neoplasms; Sarcoma; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Thymus Neoplasms; Oropharyngeal Neoplasms; Gallbladder Neoplasms; Lung Neoplasms; Prostatic Neoplasms, Castration-Resistant; Lymphoma; Penile Neoplasms; Thymoma; Urogenital Neoplasms; Metastatic breast cancer; Carcinoma, Small Cell; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Neoplasm Metastasis; Sarcoma, Kaposi; Neoplasms, Germ Cell and Embryonal; Stomach Neoplasms; Solid tumours; Hematologic Neoplasms; Head and Neck Neoplasms; Intestinal Neoplasms; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Vaginal Neoplasms; Carcinoma; Carcinoma, Renal Cell; Esthesioneuroblastoma, Olfactory; Anus Neoplasms; Biliary Tract Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Nose Neoplasms; Ganglioglioma; Papillomavirus Infections; Carcinoma, Trans Details
Nisevokitug NIS-793 Phase 3 Clinical Xoma Corp Kidney Neoplasms; Polycythemia Vera; Pancreatic Neoplasms; Myelodysplastic Syndromes; Breast Neoplasms; Colorectal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Adenocarcinoma; Thrombocythemia, Essential; Carcinoma, Hepatocellular Details
SB-01 (Ensol BioSciences) Peniel-2000; SB-01; Peniel 2K; YH14618; YH-14618; P2K Phase 3 Clinical Ensol Biosciences Inc Intervertebral Disc Degeneration; Intervertebral disc disease; Low Back Pain Details
Livmoniplimab MGH-8; AGRX-115; ABBV-151; MHG-8; ARGX-115 Phase 3 Clinical Argenx Se Solid tumours; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Dalutrafusp alfa GS-1423; AGEN-1423 Phase 2 Clinical Agenus Inc Solid tumours; Liver Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal Details
ZSP-1603 ZSP-1603 Phase 2 Clinical Wuxi Apptec Co Ltd, Guangdong Zhongsheng Pharmaceutical Co Ltd Ovarian Neoplasms; Liver Neoplasms; Solid tumours; Carcinoma, Renal Cell; Idiopathic Pulmonary Fibrosis; Colonic Neoplasms; Thyroid Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Nicousamide XLF-III-43 Phase 2 Clinical Institue Of Materia Medica Chinese Academy Of Medical Science Hypertensive nephropathy; Diabetic Nephropathies Details
Meflonidone hydrochloride Phase 2 Clinical Guangzhou Nanxin Pharma Co Ltd, Central South University Diabetes Mellitus, Type 2; Diabetic Nephropathies Details
Fluorofenidone AKF-PD Phase 2 Clinical Dierepharma HK Ltd, Hainan Haiyao Co Ltd, Central South University Liver Cirrhosis Details
Cotsiranib STP-705LU; STP-705LV; STP-705; STP-705L Phase 2 Clinical Sirnaomics, Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd Liver Neoplasms; Carcinoma, Basal Cell; Cholangiocarcinoma; Carcinoma, Basosquamous; Obesity, Abdominal; Keloid; Cicatrix, Hypertrophic; Carcinoma, Hepatocellular Details
Yinfenidone Hydrochloride HEC-585; HEC-00000585 Phase 2 Clinical Hec Pharm Co Ltd Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis Details
YL-13027 YL-13027 Phase 2 Clinical YL-Pharma Solid tumours; Pancreatic Neoplasms Details
Linavonkibart SRK-181; SRT-BETA-1-AB3 Phase 1 Clinical Scholar Rock Neoplasms Details
Charis-1000 Charis-1000; C 1K; C1K Phase 1 Clinical Ensol Biosciences Inc Breast Neoplasms Details
HLX-6018 HLX-6018; HLX6018 Phase 1 Clinical Shanghai Henlius Biopharmaceuticals Co Ltd, Shanghai Henlius Biotech Inc Idiopathic Pulmonary Fibrosis Details
RO7496353 RO7496353; RO-7496353; SOF 10; RG6440; RG-6440 Phase 1 Clinical Genentech Inc Solid tumours; Stomach Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
JYB-1907 JYB-1907 Phase 1 Clinical Jiangxi Jemincare Group Co Ltd Solid tumours Details
STP-707 STP-707; STP707 Phase 1 Clinical Sirnaomics Biopharmaceuticals (Suzhou) Co Ltd Liver Neoplasms; Solid tumours; Pancreatic Neoplasms; Liver Cirrhosis; Pulmonary Fibrosis; Cholangitis, Sclerosing Details
PXS-64 PXS-64 Phase 1 Clinical Syntara Ltd Multiple Sclerosis Details
AVID-200 AVID-200; BMS-986416; AVID-200 DP Phase 1 Clinical Formation Biologics Corp Solid tumours; Polycythemia Vera; Primary Myelofibrosis; Scleroderma, Diffuse; Thrombocythemia, Essential Details

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