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CD73

Brief Information

Name:5-nucleotidase
Target Synonym:5 Nucleotidase (CD73),5 -nucleotidase,5 -Nucleotidase, Ecto (CD73),Ecto-5 -nucleotidase,NT5E,5 -Nucleotidase Ecto,Ecto-5-Nucleotidase,5-NT,Purine 5-Prime-Nucleotidase,5-Nucleotidase, Ecto (CD73),5 Nucleotidase (CD73),5-Nucleotidase Ecto,5-Nucleotidase,CD73 Antigen,EC 3.1.3.5,CALJA,E5NT,ENT,NT,EN,CD73,5 -NT,NT5,NTE,EC:3.1.3.5
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:28
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

CD3-H52H7-SPR
 CD73 SPR

Anti-CD73 antibody (Human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human CD73 Protein, His Tag (Cat. No. CD3-H52H7) with an affinity constant of 0.164 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CD3-H52H7-BLI
 CD73 BLI

Loaded Anti-CD73 MAb (Human IgG1) on AHC Biosensor, can bind Human CD73 Protein, His Tag (Cat. No. CD3-H52H7) with an affinity constant of 0.179 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

Background

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IPH-5301 IPH-5301 Phase 1 Clinical Innate Pharma Ovarian Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Neoplasms; Breast Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Neoplasm Metastasis Details
JAB-BX102 JAB-BX102 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd Solid tumours Details
HBM-1007 HBM1007; R 1007; HBM 1007; HBM-1007 Phase 1 Clinical Harbour Biomed Solid tumours; Neoplasms Details
Interferon beta-1a (Faron Pharmaceuticals) MR-11A8; FP-1201; FP-1201-lyo Phase 2 Clinical Faron Pharmaceuticals Ltd Multiple Organ Failure; Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Mantle-Cell; Leukemia, B-Cell; Lymphoma, Non-Hodgkin; Acute Lung Injury Details
Dalutrafusp alfa AGEN-1423; GS-1423 Phase 2 Clinical Gilead Inc, Agenus Inc Solid tumours; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal Details
Dresbuxelimab AK-119 Phase 2 Clinical Akeso Pharmaceuticals Inc Solid tumours; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
PT-199 PT-199 Phase 1 Clinical Phanes Therapeutics Inc Colonic Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Lung Neoplasms; Thyroid Neoplasms; Colorectal Neoplasms; Breast Neoplasms; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Ovarian Neoplasms; Head and Neck Neoplasms Details
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb) Phase 1 Clinical Bristol-Myers Squibb Company Neoplasms Details
Mupadolimab CPX-006; COR-004 (Corvus Pharmaceuticals); CPI-006 Phase 2 Clinical Corvus Pharmaceuticals Inc Papillomavirus Infections; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Lymphoma, Non-Hodgkin; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Solid tumours; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Head and Neck Neoplasms; Ovarian Neoplasms Details
ORIC533 ORIC-533 Phase 1 Clinical Oric Pharmaceuticals Inc Multiple Myeloma; Neoplasm Metastasis Details
BPI-472372 BPI-472372 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours Details
Uprevstobart INCA-00186 Phase 1 Clinical Incyte Corp Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Gastrointestinal Neoplasms Details
BB-1709 BB-1709 Phase 1 Clinical Bliss Biopharmaceutical (Hangzhou) Co Ltd Solid tumours Details
Oleclumab MEDI-9447 Phase 3 Clinical Medimmune Llc Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma; Hemangiosarcoma; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Liposarcoma; Prostatic Neoplasms; Osteosarcoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details
Quemliclustat AB-680 Phase 2 Clinical Arcus Biosciences Inc Biliary Tract Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Cholangiocarcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Carcinoma, Pancreatic Ductal; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
BR-101 BR101; BR-101 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Solid tumours Details
S-095024 S-095024; S095024 Phase 2 Clinical Institut De Recherches Internationales Servier, Servier Bio-Innovation LLC, Regeneron Pharmaceuticals Inc Carcinoma, Non-Small-Cell Lung Details
HB-0052 HB0052; HB-0052 Phase 1 Clinical Shanghai Huaota Biopharmaceutical Co Ltd Solid tumours Details
BMS-986179 BMS-986179 Phase 2 Clinical Bristol-Myers Squibb Company Solid tumours Details
Uliledlimab TJ-004309; TJD-5; TJ-4309 Phase 2 Clinical I-Mab Biopharma Co Ltd Solid tumours; Head and Neck Neoplasms; Ovarian Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms Details
CB-708 CB-708; CB708; ATG-037 Phase 1 Clinical Calithera Biosciences Inc Solid tumours; Neoplasms Details
HLX-23 HLX-23 Phase 1 Clinical Shanghai Henlius Biologics Co Ltd Solid tumours; Lymphoma Details
IBI-325 IBI-325 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
ABSK-051 ABSK051 Phase 1 Clinical ABbisko Therapeutics Co Ltd Solid tumours; Neoplasms Details
LY-3475070 LY-3475070 Phase 1 Clinical Eli Lilly And Company Neoplasms Details
PM-1015 PM1015; PM-1015 Phase 1 Clinical Biotheus Inc Solid tumours Details
AK-131 AK-131 Phase 1 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Neoplasms Details

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