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Your Position: Home > CD73

CD73

Brief Information

Name:5-nucleotidase
Target Synonym:5 Nucleotidase (CD73),5 -nucleotidase,5 -Nucleotidase, Ecto (CD73),Ecto-5 -nucleotidase,NT5E,5 -Nucleotidase Ecto,Ecto-5-Nucleotidase,5-NT,Purine 5-Prime-Nucleotidase,5-Nucleotidase, Ecto (CD73),5 Nucleotidase (CD73),5-Nucleotidase Ecto,5-Nucleotidase,CD73 Antigen,EC 3.1.3.5,CALJA,E5NT,ENT,NT,EN,CD73,5 -NT,NT5,NTE,EC:3.1.3.5
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

CD3-H52H7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-CD73 antibody (Human IgG1) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human CD73, His Tag (HPLC-verified) (Cat. No. CD3-H52H7) with an affinity constant of 0.164 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CD3-H52H7-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Anti-CD73 MAb (Human IgG1) on AHC Biosensor, can bind Human CD73, His Tag (HPLC-verified) (Cat. No. CD3-H52H7) with an affinity constant of 0.179 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

CD73,NT5E,5'-Nucleotidase,5'-NT,NT5,NTE

Background

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb) Phase 1 Clinical Neoplasms Details
BR-101 BR101; BR-101 Phase 1 Clinical BioRay Pharmaceutical Co Ltd Solid tumours Details
SRF-373(Surface Oncology) SRF-373; NZV-930 Surface Oncology Details
IPH-5301 IPH-5301 Phase 1 Clinical Innate Pharma Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Neoplasm Metastasis Details
IBI-325 IBI-325 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours Details
INCA-00186 INCA-00186 Incyte Corp Ltd Details
Uliledlimab TJ-004309; TJD-5; TJ-4309 Phase 2 Clinical I-Mab Biopharma Co Ltd Solid tumours Details
BMS-986179 BMS-986179 Bristol-Myers Squibb Company Details
LY-3475070 LY-3475070 Eli Lilly And Company Details
Dalutrafusp alfa GS-1423; AGEN-1423 Gilead Details
PT-199 PT-199 Phase 1 Clinical Phanes Therapeutics Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
Mupadolimab CPI-006 Phase 2 Clinical Corvus Head and Neck Neoplasms; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Papillomavirus Infections; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Urinary Bladder Neoplasms; Sarcoma; Prostatic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
PM-1015 PM1015; PM-1015 Phase 1 Clinical Biotheus Inc Solid tumours Details
Quemliclustat AB-680 Phase 2 Clinical Arcus Biosciences Inc, Gilead Sciences Inc Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms Details
Oleclumab MEDI-9447 Phase 3 Clinical Medimmune Llc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma; Carcinoma, Renal Cell; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
Dresbuxelimab AK-119 Phase 1 Clinical Akeso Pharmaceuticals Inc Solid tumours; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis Details
JAB-BX102 JAB-BX102 Phase 2 Clinical Jacobio Pharmaceuticals Co Ltd Solid tumours Details
CB-708 CB-708; CB708; ATG-037 Phase 1 Clinical Calithera Biosciences Inc Solid tumours; Neoplasms Details

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