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Brief Information

Name:Platelet-derived growth factor subunit B
Target Synonym:Epididymis Secretory Sperm Binding Protein,Becaplermin,PDGF-2,PDGFB,Platelet Derived Growth Factor Subunit B,Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog),Platelet-Derived Growth Factor B Chain,Proto-Oncogene C-Sis,PDGF Subunit B,PDGF2,SIS,Platelet-Derived Growth Factor Subunit B,Platelet-Derived Growth Factor 2,PDGF, B Chain,Oncogene SIS,IBGC5,C-Sis,SSV,Platelet-Derived Growth Factor Beta Polypeptide,Platelet-Derived Growth Factor, Beta Polypept
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
PDB-H4112 Human Human PDGF-BB Protein, premium grade
PDB-H5127 Human Unconjugated Human PDGF-BB Protein, His,Avitag™
ACRO Quality

Part of Bioactivity data

PDB-H4112-Cell-based assay

Human PDGF-BB, premium grade (Cat. No. PDB-H4112) stimulates proliferation of NIH/3T3 cells. The specific activity of Human PDGF-BB, premium grade is >5.0 x 10^5 IU/mg, which is calibrated against human PDGF-BB WHO International Standard (NIBSC code: 94/728) (QC tested).


Immobilized Unconjugated Human PDGF-BB, His,Avitag (Cat. No. PDB-H5127) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.5-16 ng/mL (QC tested).


Immobilized Human PDGF-BB, premium grade (Cat. No. PDB-H4112) at 1 μg/mL (100 μL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.6-10 ng/mL (QC tested).

Synonym Name



PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HL-217 HL-217; KR-31831 Phase 1 Clinical Korea Research Institute Of Chemical Technology Macular Degeneration Details
Ilorasertib ABT-348; A-9686600; Abbott-968660 Phase 2 Clinical Abbvie Inc Solid tumours; Leukemia, Myelogenous, Chronic; Neoplasms; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Chronic, B-Cell Details
SHP-627 SHP-627; FT-011; FT-11; FT-001 Phase 2 Clinical Shire Pharmaceuticals Scleroderma, Systemic; Retinal Degeneration; Scleroderma, Diffuse Details

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