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Your Position: Home > Properdin

Properdin

Brief Information

Name:Properdin
Target Synonym:Complement factor P,CFP
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
PRN-R52H6 Rhesus macaque Rhesus macaque Properdin Protein, His Tag
PRN-R52H6-structure
PRN-R52H6-sds
PRN-M52H5 Mouse Mouse Properdin Protein, His Tag
PRN-M52H5-structure
PRN-M52H5-sds
PRN-H52H3 Human Human Properdin Protein, His Tag
PRN-H52H3-structure
PRN-H52H3-sds
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Synonym Name

Properdin,Complement factor P,CFP,PFC

Background

Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates(PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NM-5072 NM5072; NM-5072 Phase 1 Clinical NovelMed Therapeutics Inc Hemoglobinuria, Paroxysmal; Atypical Hemolytic Uremic Syndrome; Eye Diseases Details
Tarperprumig ALXN-1820 Phase 1 Clinical Alexion Pharmaceuticals Inc Anemia, Sickle Cell Details

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