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Your Position: Home > IL-31 RA

IL-31 RA

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Part of Bioactivity data

ILA-H52H7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

ILA-H52H7-MALS-HPLC
Human IL-31 RA, His Tag (Cat. No. ) MALS images

The purity of Human IL-31 RA, His Tag(Cat. No. ILA-H52H7) is more than 90% and the molecular weight of this protein is around 80-100 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL-31R-alpha,Gp130-like receptor

Background

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

Clinical and Translational Updates

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