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Glypican 2

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Part of Bioactivity data

GP2-H5255-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human FGF acidic, Tag Free immobilized (Cat. No. AFF-H4116) on CM5 Chip can bind Human Glypican 2, Fc Tag (Cat. No. GP2-H5255) with an affinity constant of 15 nM as determined in a SPR assay (Biacore 8K) (QC tested).

GP2-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Glypican 2, Fc Tag (Cat. No. GP2-H5255) on Protein A Biosensor, can bind Human FGF basic, Tag Free (Cat. No. BFF-H4117) with an affinity constant of 0.3 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

Glypican 2,GPC2

Background

Glypican 2 (GPC2), also known cerebroglycan,  is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/?-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Clinical and Translational Updates

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