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Your Position: Home > Siglec-8

Siglec-8

Brief Information

Name:Sialic acid-binding Ig-like lectin 8
Target Synonym:Sialic acid-binding Ig-like lectin 8,SIGLEC8,SAF2,Sialoadhesin family member 2,SAF-2,Sialic Acid Binding Ig Like Lectin 8,Sialic Acid Binding Ig-Like Lectin 8,SIGLEC8L,Siglec-8,MGC59785
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
SI8-H82E9 Human Biotinylated Human Siglec-8 Protein, His,Avitag™
SI8-H82E9-structure
SI8-H82E9-sds
SI8-H5254 Human Human Siglec-8 Protein, Fc Tag
SI8-H5254-structure
SI8-H5254-sds
SI8-H52H8 Human Human Siglec-8 Protein, His Tag (MALS verified)
SI8-H52H8-structure
SI8-H52H8-sds
ACRO Quality

Part of Bioactivity data

SI8-H52H8-SPR
Siglec-8 MALS images

The purity of Human Siglec-8, His Tag (Cat. No. SI8-H52H8) is more than 85% and the molecular weight of this protein is around 102-125 kDa verified by SEC-MALS.

Synonym Name

Siglec-8,SAF-2,SIGLEC8,SAF2

Background

Siglec-8 is also known as  SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AK-001 AK-001 Phase 3 Clinical Allakos Inc Respiratory Tract Infections; Nasal Polyps; Urinary Tract Infections; Community Acquired Pneumonia; Hypersensitivity Details
Lirentelimab AK-002; AK 002 Phase 2 Clinical Johns Hopkins University School Of Medicine Eosinophilic gastroenteritis (EG); Chronic Urticaria; Mastocytosis, Systemic; Conjunctivitis, Allergic; Eosinophilic Esophagitis; Duodenitis; Keratoconjunctivitis; Dermatitis, Atopic Details

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