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Siglec-8

Siglec-8 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
SI8-H5254 Human Human Siglec-8 Protein, Fc Tag
SI8-H5254-structure
SI8-H52H8 Human Human Siglec-8 Protein, His Tag
SI8-H52H8-structure

Siglec-8 Molecule Synonym Name

Siglec-8,SAF-2,SIGLEC8,SAF2

Siglec-8 Molecule Background

Siglec-8 is also known as  SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8 References

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