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Your Position: Home > NKG2D

NKG2D

Brief Information

Name:NKG2-D type II integral membrane protein
Target Synonym:Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor,CD314,D12S2489E,KLR,DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence,Killer Cell Lectin Like Receptor K1,NKG2-D,Killer Cell Lectin-Like Receptor Subfamily K, Member 1,KLRK1,CD314 Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

NKD-H5257-ELISA
Human NKG2D, Llama IgG2b Fc TagHuman NKG2D, Llama IgG2b Fc Tag (Cat. No. NKD-H5257) ELISA bioactivity

Immobilized Human MICA, His Tag (Cat. No. MIA-H5221) at 5 μg/mL (100 μL/well) can bind Human NKG2D, Llama IgG2b Fc Tag (Cat. No. NKD-H5257) with a linear range of 0.01-0.625 μg/mL (QC tested).

NKD-H82F4-MALS-HPLC
Biotinylated Human NKG2D, Avitag,Fc Tag (Cat. No. ) MALS images

The purity of Biotinylated Human NKG2D, Avitag,Fc Tag (Cat. No. NKD-H82F4) is more than 90% and the molecular weight of this protein is around 100-122 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human NKG2D, Avitag,Fc TagBiotinylated Human NKG2D, Avitag,Fc Tag (Cat. No. NKD-H82F4) ELISA bioactivity

Immobilized Human MICA, Fc Tag (Cat. No. MIA-H5253) at 5 μg/mL (100 μL/well) can bind Biotinylated Human NKG2D, Avitag,Fc Tag (Cat. No. NKD-H82F4) with a linear range of 0.6-20 ng/mL (QC tested).

Synonym Name

NKG2D,CD314,KLRK1,NK cell receptor D

Background

NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NKG2D CAR-T cell therapy (Uwell Biopharma) UWN2D Clinical Uwell Biopharma Neoplasms Details
NKG2D CAR-T Cell therapy (Yake Biotechnology) Phase 1 Clinical Shanghai YaKe Biotechnology Co Ltd Leukemia, Myeloid, Acute Details
NKG2D-ACE2 CAR-NK cell therapy (Sidemu Biotechnology Technology) Chongqing Sidemu Biotechnology Technology Co Ltd Details

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