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Brief Information

Name:NK cell lectin-like receptor subfamily C member 1
Target Synonym:CD159a,NKG2A,KLRC1,Killer Cell Lectin Like Receptor C1,Killer Cell Lectin-Like Receptor Subfamily C, Member 1,CD159 Antigen-Like Family Member A,NKG2-1/B Activating NK Receptor,NKG2-A/B-Activating NK Receptor,NK Cell Receptor A,NKG2-A/NKG2-B Type II Integral Membrane Protein,NKG2-A/B Type II Integral Membrane Protein,Natural Killer Group Protein 2,Natural Killer Cell Lectin,C-Lectin Type II Protein,CD159a Antigen,NKG2,NKG2-B,NKG2-A
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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Synonym Name

NKG2A,CD159a,KLRC1,NK cell receptor A


NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2-A/NKG2-B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL-10, which was present at a high level in the plasma of HCC patients. Blocking IL-10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Monalizumab NN-8765; IPH-2201; NNC-0141-0000-0100 Phase 3 Clinical Innate Pharma, Novo Nordisk A/S Colorectal Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Esophageal Squamous Cell Carcinoma; Carcinoma, Small Cell; Mouth Neoplasms; Carcinoma, Squamous Cell; Esophageal adenocarcinoma; Inflammation; Head and Neck Neoplasms; Genital Neoplasms, Female; Breast Neoplasms; Arthritis, Rheumatoid; Small Cell Lung Carcinoma; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Hematologic Neoplasms Details
BMS-986315 BMS-986315 Phase 2 Clinical Bristol-Myers Squibb Company Solid tumours; Carcinoma, Non-Small-Cell Lung Details
S-095029 S-095029 Phase 2 Clinical Institut De Recherches Internationales Servier Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Mismatch Repair Deficient Cancer; Microsatellite instability-high cancer; Carcinoma, Non-Small-Cell Lung Details
BRY-805 BRY805; BRY-805 Phase 1 Clinical Hisun Biopharmaceutical Co Ltd, BioRay Pharmaceutical Co Ltd Solid tumours Details
HY000102 HY-0102; HY-000102 Phase 1 Clinical Shanghai HyaMab Biotech Co Ltd Solid tumours Details

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