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Your Position: Home > MERTK

MERTK

Brief Information

Name:Tyrosine-protein kinase Mer
Target Synonym:EC 2.7.10,MER,MERTK,C-Mer Proto-Oncogene Tyrosine Kinase,Receptor Tyrosine Kinase MerTK,Tyrosine-Protein Kinase Mer,EC 2.7.10.1,STK Kinase,EC:2.7.10.1,Proto-oncogene c-Mer,MER Proto-Oncogene, Tyrosine Kinase,MER Receptor Tyrosine Kinase,Tyro12,C-Eyk,C-Mer,RP38,c-Mer Tyrosine Kinase
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
MEK-H5253 Human Human MERTK / Mer Protein, Fc Tag
MEK-H5253-structure
MEK-H5253-sds
MEK-C5253 Cynomolgus Cynomolgus MERTK / Mer Protein, Fc Tag (MALS verified)
MEK-C5253-structure
MEK-C5253-sds
MEK-M5253 Mouse Mouse MERTK / Mer Protein, Fc Tag (MALS verified)
MEK-M5253-structure
MEK-M5253-sds
MEK-H52H6 Human Human MERTK / Mer Protein, His Tag
MEK-H52H6-structure
MEK-H52H6-sds

Part of Bioactivity data

MEK-C5253-MALS-HPLC
Cynomolgus MERTK, Fc Tag (Cat. No. ) MALS images

The purity of Cynomolgus MERTK, Fc Tag (Cat. No. MEK-C5253) is more than 90% and the molecular weight of this protein is around 206-251 kDa verified by SEC-MALS.

Report
  • Background
    Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    MEK-M5253-MALS-HPLC
    Mouse MERTK, Fc Tag (Cat. No. ) MALS images

    The purity of Mouse MERTK, Fc Tag (Cat. No. MEK-M5253) is more than 90% and the molecular weight of this protein is around 198-242 kDa verified by SEC-MALS.

    Report

Synonym Name

MERTK,Mer

Background

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Cabozantinib S-malate XL-184; BMS-907351 Approved Exelixis Inc Cometriq, Cabometyx Japan Carcinoma, Renal Cell Takeda 2012-11-29 Thyroid Neoplasms; Adenocarcinoma, Follicular; Brain Neoplasms; Sarcoma; Neuroblastoma; Neurofibroma, Plexiform; Prostatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Bile Duct Neoplasms; Central Nervous System Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Glioma; Carcinoma, Neuroendocrine; Carcinoma, Hepatocellular; Neoplasms, Germ Cell and Embryonal; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Thyroid Cancer, Papillary; Meningioma; Carcinoma, Transitional Cell; Kidney Neoplasms; Ovarian germ cell tumor; Bone metastases; Carcinoma, Renal Cell; Rejection of liver transplantation; Esophageal Neoplasms; Pain; Stomach Neoplasms; Carcinoma, Merkel Cell; Glioblastoma; Seminoma; Solid tumours; Neurofibromatoses; Neoplasms; Salivary Gland Neoplasms; Carcinoma, Papillary; Skin Neoplasms; Kidney Diseases; Neuroendocrine Tumors; Adrenocortical Carcinoma; Prostatic Neoplasms, Castration-Resistant; Multiple Myeloma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
INCB-081776 INCB-81776; INCB-081776 Incyte Corp Details
MRX-2843 MRX-2843; UNC-2025; UNC-2371 Phase 1 Clinical Meryx, University Of North Carolina At Chapel Hill, University Of Colorado At Denver Solid tumours; Leukemia, Myeloid, Acute Details

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