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MERTK

Brief Information

Name:Tyrosine-protein kinase Mer
Target Synonym:Tyro12,C-Eyk,C-Mer,RP38,c-Mer Tyrosine Kinase,MER,MERTK,C-Mer Proto-Oncogene Tyrosine Kinase,Receptor Tyrosine Kinase MerTK,Tyrosine-Protein Kinase Mer,EC 2.7.10.1,STK Kinase,EC 2.7.10,Proto-oncogene c-Mer,MER Proto-Oncogene, Tyrosine Kinase,MER Receptor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

MEK-C5253-MALS-HPLC
Cynomolgus MERTK, Fc Tag (Cat. No. ) MALS images

The purity of Cynomolgus MERTK, Fc Tag (Cat. No. MEK-C5253) was more than 90% and the molecular weight of this protein is around 206-251 kDa verified by SEC-MALS.

  • Background
    Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    MEK-M5253-MALS-HPLC
    Mouse MERTK, Fc Tag (Cat. No. ) MALS images

    The purity of Mouse MERTK, Fc Tag (Cat. No. MEK-M5253) was more than 90% and the molecular weight of this protein is around 198-242 kDa verified by SEC-MALS.

Synonym Name

MERTK,Mer

Background

Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
INCB-081776 INCB-81776; INCB-081776 Phase 1 Clinical Incyte Corp Solid tumours Details
MRX-2843 MRX-2843; UNC-2025; UNC-2371 Phase 1 Clinical Meryx, University Of North Carolina At Chapel Hill, University Of Colorado At Denver Solid tumours; Leukemia; Pathologic Processes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplastic Processes; Leukemia, Myeloid, Acute; Neoplasm Metastasis Details

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