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Your Position: Home > Glycoprotein B / gB

Glycoprotein B / gB

Brief Information

Name:Glycoprotein B of human cytomegalovirus
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Part of Bioactivity data

CMB-V52H4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-glycoprotein B antibody-SM5-1 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind HCMV (strain AD169) Glycoprotein B (gB), His Tag (Cat. No. CMB-V52H4) with an affinity constant of 5.59 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

CMB-V52H4-ELISA
HCMV (strain AD169) Glycoprotein B (gB), His TagHCMV (strain AD169) Glycoprotein B (gB), His Tag (Cat. No. CMB-V52H4) ELISA bioactivity

Immobilized HCMV (strain AD169) Glycoprotein B (gB), His Tag (Cat. No. CMB-V52H4) at 1 μg/mL (100 μL/well) can bind Anti-gB(HCMV)-antibody-SM5-1,Human IgG1(AM330) with a linear range of 0.1-4 ng/mL (QC tested).

Synonym Name

Glycoprotein B,gB,Envelope glycoprotein B

Background

Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. CMV Virus Envelope Glycoportein B (CMV-GB) can be cleaved into glycoprotein GP55. Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. CMV-GB may be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Furthermore, CMV-GB can interact with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also, CMV-GB participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.

Clinical and Translational Updates

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