About PEGS Europe
Network with 1,200+ colleagues at PEGS Europe, the largest protein & antibody engineering event in Europe, which has been described as "the best biologics technology meeting in Europe." Last year, nearly 900 delegates from 35 countries, including 78% from pharma and biotech organizations, convened in beautiful Barcelona and online to discuss the latest advances in protein and antibody engineering.
ACROBiosystems sponsored the 2022 PEGS EUROPE, and will give a presentation on day 3 of the event in the TARGET STREAM program.
The PEGS Europe Membrane Protein track provides a forum in which discovery biologists and protein engineers can come together to discuss next-generation strategies and technologies that will allow biologic drugs for these target families to advance into the clinic and beyond.
Speaker: Dr. Wenlin Ren, Senior Product Development Manager at ACROBiosystems.
Time: 16:30(CET,GMT+1), 14 November 2022
Topic: Overcoming Challenges in Developing Full-Length Multi-Pass Transmembrane Proteins
Full-length, biologically active, multi-pass transmembrane proteins (TPs) are one of the most challenging types of proteins to develop due to its innately complex structure and assortment of hydrophobic and hydrophilic regions. Furthermore, difficulties such as low-expression levels contribute to complications in purification and solubility. However, in recent years, multi-pass transmembrane proteins have been highlighted as a major therapeutic target in developing immunotherapies.
The role of TPs as a molecular gatekeeper, selectively transporting molecules and receiving external messages, plays a critical function in regulating cell metabolism, cellular activity, and cellular fate. This is further evidenced by more than 50% of pharmaceuticals targeting multi-pass TPs, including CD20, G Protein-coupled receptors (GPCRs), ion channels, and others.
To overcome the challenges in developing high-quality and bioactive multi-pass TPs, we needed to re-design our entire development system and optimize the expression level, system, and culture conditions. Furthermore, ACROBiosystems also specially built a comprehensive platform solution for the R&D and production of multi-pass transmembrane proteins, including VLP technology platform, detergent micelle technology platform and Nanodisc technology platform. As a result, a series of full-length multi-pass transmembrane proteins was successfully developed with native conformation and high bioactivity based on our platforms.
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