Mouse CD28 Protein, His Tag
Mouse CD28, His Tag (CD8-M52H6) is expressed from human 293 cells (HEK293). It contains AA Asn 20 - Lys 149 (Accession # P31041-1).
Predicted N-terminus: Asn 20
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 16.9 kDa. The protein migrates as 30-35 kDa and 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Less than 1.0 EU per μg by the LAL method.
>90% as determined by SDS-PAGE.
Mouse CD28, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Mouse CD28, His Tag (Cat. No.
CD8-M52H6) at 5 μg/mL (100 μL/well) can bind Mouse B7-1, Fc Tag (Cat. No. CD0-M5259) with a linear range of 0.156-5 μg/mL (QC tested).
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
(1) Woerly G., et al., 2002, J Leukoc Biol 72 (4): 769–79. (2) Nunès, J A., et al., 1996, J. Biol. Chem. (UNITED STATES) 271 (3): 1591–8. (3) Ellis, J H., et al., 2000, J. Immunol. (UNITED STATES) 164 (11): 5805–14.
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