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CD28

CD28 Molecule Information

Name:T-cell-specific surface glycoprotein CD28
Target Synonym:CD28;T-cell-specific surface glycoprotein CD28;TP44;CD_antigen=CD28
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase ?

CD28 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CD8-H52Hc Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, His Tag
CD8-H52Hc-structure
CD8-H52Hc-sds
CD8-H52Hc-elisa_1
CD8-H525a Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc Tag (HPLC-verified)
CD8-H525a-structure
CD8-H525a-sds
CD8-H525a-hplc
CD8-H525a-elisa_1
CD8-H525a-elisa_2
CD8-H52A5 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque CD28 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD8-H52A5-structure
CD8-H52A5-sds
CD8-H52A5-elisa_1
CD8-H82F2 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque CD28 Protein, Fc,Avitag™
CD8-H82F2-structure
CD8-H82F2-sds
CD8-H82F2-elisa_1
CD8-M5257 Mouse Mouse CD28 Protein, Fc Tag
CD8-M5257-structure
CD8-M5257-sds
CD8-M5257-elisa_1
CD8-M52H6 Mouse Mouse CD28 Protein, His Tag
CD8-M52H6-structure
CD8-M52H6-sds
CD8-M52H6-elisa_1

CD28 Molecule Synonym Name

CD28,Tp44

CD28 Molecule Background

T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

CD28 References

CD28 Related Molecule

CD28 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-BCMA CAR T cell therapy (Wuhan Bio-Raid Biotechnology) Phase Not Specified Wuhan Bio-Raid Biotechnology hematological malignancies Details
Abatacept (Orban Biotech) Phase Ⅱ The National Institute of Diabetes and Digestive and Kidney Diseases, Orban Biotech Type 1 diabetes Details
FPT-155 CD80-Fc; FPT-155 Phase Ⅰ Five Prime Therapeutics Solid tumours Details
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) Phase Ⅰ City of Hope National Medical Center Non-Hodgkin's lymphoma (NHL) Details
Recombinant CD28 (CytoMed) Phase Not Specified CytoMed Autoimmune diseases, Rheumatoid arthritis (RA), Allergic diseases, Prophylaxis of organ rejection Details
TGN-1412 TGN-1412 Phase Ⅰ TeGenero Cancer Details
Lulizumab pegol BMS-931699; Lulizumab Phase Ⅱ Bristol-Myers Squibb Sjoegren's syndrome, Systemic lupus erythematosus Details
Anti-CD28/anti-HMV-MAA bispecific antibody (Eberhard-Karls-Universitaet Tuebingen) rM28; r28M Phase Ⅱ Eberhard-Karls Universitaet Tuebingen Cancer Details
ALPN-101 ALPN-101 Phase Ⅰ Alpine Immune Sciences Autoimmune diseases, Inflammation Details
ALPN-202 ALPN-202 Preclinical Alpine Immune Sciences Cancer Details
B7-2/GM-CSF cancer gene therapy CIT Phase Ⅰ Radient Solid tumours Details
FR-104 FR-104; JNJ-3133,FR104; JNJ3133 Phase Ⅱ Effimune, Janssen, Biomedical Primate Research Center, OSE Immunotherapeutics Transplant rejection, Rheumatoid arthritis (RA) Details
Theralizumab TAB-08; TABO-8 Phase Ⅱ TheraMAB Plaque psoriasis, Systemic lupus erythematosus Details
Membrane bound ligand T-SIGn virus NG-348 Phase Ⅰ PsiOxus Therapeutics, Bristol-Myers Squibb Solid tumours Details
Reltecimod AB-103; P2-TA Phase Ⅲ Atox Bio Acute kidney injury, Soft tissue infections, Peritonitis Details

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