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CD28

CD28 Molecule Information

Name:T-cell-specific surface glycoprotein CD28
Target Synonym:CD28;T-cell-specific surface glycoprotein CD28;TP44;CD_antigen=CD28
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase ?

CD28 Part of Bioactivity data

CD8-H525a-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (HPLC-verified) (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, His Tag (Cat. No. B71-H5228) with an affinity constant of 5.29 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

CD8-H525a-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (HPLC-verified) (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. B71-H52A4) with an affinity constant of 2.72 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

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CD28 Molecule Synonym Name

CD28,Tp44

CD28 Molecule Background

The Anti-hCD28 MAb is also known as ACM28, and have been shown to have a strong adjuvant effect when conjugated to an immunogen. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement. Anti-hCD28 MAb can be used, together with antigen, to co-stimulate specific T cells. The anti-CD28 mAb (Cat # CD8-MKP5a) can also be used together with anti-CD3 mAb (Cat # CDE-M353b) for polyclonal activation of T cells. Suitable anti-CD3 mAbs to use are mAb CD3-2 for human T cells and mAb CD3-1 for macaque T cells.

CD28 References

CD28 Related Molecule

CD28 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-BCMA CAR T cell therapy (Wuhan Bio-Raid Biotechnology) Phase Not Specified Wuhan Bio-Raid Biotechnology hematological malignancies Details
Abatacept (Orban Biotech) Phase Ⅱ The National Institute of Diabetes and Digestive and Kidney Diseases, Orban Biotech Type 1 diabetes Details
FPT-155 CD80-Fc; FPT-155 Phase Ⅰ Five Prime Therapeutics Solid tumours Details
Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells (City of Hope Medical Center) Phase Ⅰ City of Hope National Medical Center Non-Hodgkin's lymphoma (NHL) Details
Recombinant CD28 (CytoMed) Phase Not Specified CytoMed Autoimmune diseases, Rheumatoid arthritis (RA), Allergic diseases, Prophylaxis of organ rejection Details
TGN-1412 TGN-1412 Phase Ⅰ TeGenero Cancer Details
Lulizumab pegol BMS-931699; Lulizumab Phase Ⅱ Bristol-Myers Squibb Sjoegren's syndrome, Systemic lupus erythematosus Details
Anti-CD28/anti-HMV-MAA bispecific antibody (Eberhard-Karls-Universitaet Tuebingen) rM28; r28M Phase Ⅱ Eberhard-Karls Universitaet Tuebingen Cancer Details
ALPN-101 ALPN-101 Phase Ⅰ Alpine Immune Sciences Autoimmune diseases, Graft versus host disease, Inflammation Details
ALPN-202 ALPN-202 Phase Ⅰ Alpine Immune Sciences Cancer Details
B7-2/GM-CSF cancer gene therapy CIT Phase Ⅰ Radient Solid tumours Details
FR-104 FR-104; JNJ-3133,FR104; JNJ3133 Phase Ⅱ Effimune, Janssen, Biomedical Primate Research Center, OSE Immunotherapeutics Transplant rejection, Rheumatoid arthritis (RA) Details
Theralizumab TAB-08; TABO-8 Phase Ⅱ TheraMAB Plaque psoriasis, Systemic lupus erythematosus Details
Membrane bound ligand T-SIGn virus NG-348 Phase Ⅰ PsiOxus Therapeutics, Bristol-Myers Squibb Solid tumours Details
Reltecimod AB-103; P2-TA Phase Ⅲ Atox Bio Acute kidney injury, Soft tissue infections, Peritonitis Details

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