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Your Position: Home > Receptor Tyrosine Kinases > ROR1 > Human ROR1 (165-305, Frizzled domain) Protein

Human ROR1 (165-305, Frizzled domain) Protein

  • Synonym
    ROR1,NTRKR1
  • Source
    Human ROR1 (165-305, Frizzled domain), His Tag (RO1-H5222) is expressed from human 293 cells (HEK293). It contains AA Glu 165 - Asp 305 (Accession # Q01973).
    Predicted N-terminus: Glu 165
  • Molecular Characterization
    ROR1(Glu 165 - Asp 305) Q01973

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 16.7 kDa. The protein migrates as 21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;

    2. -70°C for 3 months under sterile conditions after reconstitution.

SDS-PAGE
Human ROR1 (165-305, Frizzled domain), His Tag (Cat. No. RO1-H5222) SDS-PAGE gel

Human ROR1 (165-305, Frizzled domain), His Tag on SDS-PAGE  under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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