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Your Position: Home > CAR-T > FMC63 > FM3-Y45P1

Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293) DMF Filed

  • Source
    Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-Y45P1) is expressed from human 293 cells.
  • Isotype
    IgG1/kappa
  • Specificity
    Specifically recognizes the antigen-recognition domain of FMC63 derived CARs.
  • Application
    Flow Cytometry (Evaluation of Anti-CD19 (FMC63 scFv) CAR Expression).
    *The Isotype control (Cat. No. DNP-M1A1) is sold separately and you can follow this link for product information.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4. Normally trehalose is added as protectant before lyophilization.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. 20°C to -70°C for 12 months in lyophilized state;

    2. -70°C for 6 months under sterile conditions after reconstitution.

Bioactivity-FACS
FACS assay shows that recombinant Biotinylated FACS

2e5 of Anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Cat. No. FM3-Y45P1) and isotype control respectively, washed and then followed by PE anti-mouse IgG1 antibody and analyzed with FACS (QC tested).

  • Background
    FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.
  • Clinical and Translational Updates

      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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