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Your Position: Home > ADA > Adalimumab > ADB-Y23b

Anti-Adalimumab Antibodies (AY23b) (recommended for PK/PD)

  • Source
    Anti-Adalimumab Antibodies (recommended for PK/PD) (ADB-Y23b) is expressed from human 293 cells.
  • Isotype
    IgG1/kappa
  • Specificity
    Recognizes Adalimumab specifically, no cross reactivity with other humanized antibodies.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 years under sterile conditions after reconstitution.
SDS-PAGE
Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ADB-Y23b) SDS-PAGE gel

Anti-Adalimumab Antibodies (recommended for PK/PD) on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ) MALS images

The purity of Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ADB-Y23b) is more than 90% and the molecular weight of this protein is around 135-160 kDa verified by SEC-MALS.

Bioactivity-ELISA
Anti-Adalimumab Antibodies (recommended for PK/PD)Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ADB-Y23b) ELISA bioactivity

Immobilized Adalimumab at 1 μg/mL (100 μL/well) can bind Adalimumab Antibodies (recommended for PK/PD)(Cat. No. ADB-Y23b) with a linear range of 0.2-3 ng/mL (QC tested).

Anti-Adalimumab Antibodies (recommended for PK/PD)Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ADB-Y23b) ELISA bioactivity

Immobilized Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ADB-Y23b) at 2 μg/mL, add increasing concentrations of Adaliumumab and then add Biotinylated Anti-Adalimumab Antibodies (recommended for PK/PD) (Cat. No. ADB-BY17) at 2 μg/mL. Detection was performed using HRP-conjugated streptavidin with sensitivity of 4 ng/mL (QC tested).

  • Background
    Adalimumab is a human monoclonal antibody against TNF-alpha. It is produced by recombinant DNA technology using a mammalian cell expression system. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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