|EP131-C03||Biotinylated Human CD155||35μg|
|EP131-C04||Anti-TIGIT Neutralizing Antibody||20μg|
The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
Your experiment will include 4 simple steps:
a) Coat the plate with human TIGIT.
b) Add your molecule of interest to the tests.
c) Add human CD155-Biotin to bind the coated human TIGIT.
d) Add Streptavidin-HRP followed by TMB or other colorimetric HRP substrate.
Finally, the half maximal inhibitory concentration (IC50) of your compound to TIGIT: CD155 binding will be determined by comparing OD readings among different experimental groups.
TIGIT: CD155 [BIOTINYLATED] BINDING IN THE ABSENCE OF INHIBITORS
Immobilized human TIGIT protein at 0.7 μg/mL (100 μL/well) can bind biotinylated human CD155 with a linear range of 0.005-10 μg/mL when detected by Streptavidin-HRP. Background was subtracted from data points before curve fitting (QC tested).
INHIBITION OF TIGIT: CD155 [BIOTINYLATED] BINDING BY ANTI-TIGIT NEUTRALIZING ANTIBODY
Serial dilutions of Anti-TIGIT Neutralizing antibody (Catalog # EP131-C04) (1:1 serial dilution, from 5 μg/mL to 0.01μg/mL) was added into TIGIT: Biotinylated CD155 binding reactions. The assay was performed according to the protocol described below. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).
Price(USD) : $650.00
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