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TIGIT

TIGIT Molecule Information

Name:T cell immunoglobulin and ITIM domains
Target Synonym:VSTM3?V-set and transmembrane domain-containing protein 3?VSIG9?V-set and immunoglobulin domain-containing protein 9?TIGIT
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

TIGIT Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
TIT-C52H7 Canine Canine TIGIT Protein, His Tag
TIT-C52H7-structure
TIT-C52H7-sds
TIT-C52H7-elisa_1
TIT-H5253 Human Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin
TIT-H5253-structure
TIT-H5253-sds
TIT-H5253-elisa_1
TIT-R5259 Rabbit Rabbit TIGIT Protein, Fc Tag
TIT-R5259-structure
TIT-R5259-sds
TIT-R5259-elisa_1
TIT-R5258 Rat Rat TIGIT Protein, Fc Tag
TIT-R5258-structure
TIT-R5258-sds
TIT-R5258-elisa_1
TIT-C5254 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag
TIT-C5254-structure
TIT-C5254-sds
TIT-C5254-elisa_1
TIT-H82E5 Human Biotinylated Human TIGIT Protein, Avitag™,His Tag (recommended for biopanning)
TIT-H82E5-structure
TIT-H82E5-sds
TIT-H82E5-elisa_1
TIT-C5223 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque TIGIT Protein, His Tag (HPLC-verified)
TIT-C5223-structure
TIT-C5223-sds
TIT-C5223-hplc
TIT-C5223-elisa_1
TIT-H82F1 Human Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag (Avitag™)
TIT-H82F1-structure
TIT-H82F1-sds
TIT-H82F1-elisa_1
TIT-M52E6 Mouse Mouse TIGIT Protein
TIT-M52E6-structure
TIT-M52E6-sds
TIT-M5257 Mouse Mouse TIGIT Protein, Fc Tag
TIT-M5257-structure
TIT-M5257-sds
TIT-M5257-elisa_1
TIT-H52H3 Human Human TIGIT Protein, His Tag
TIT-H52H3-structure
TIT-H52H3-sds
TIT-H52H3-elisa_1
TIT-H52H3-elisa_2
TIT-H5254 Human Human TIGIT Protein, Fc Tag
TIT-H5254-structure
TIT-H5254-sds
TIT-H5254-elisa_1

TIGIT Molecule Synonym Name

TIGIT,VSIG9,VSTM3

TIGIT Molecule Background

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

TIGIT References

TIGIT Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Tiragolumab MTIG-7192A; RG-6058; RO-7092284 Phase Ⅰ Genentech Solid tumours Details
AB-154 AB-154 Phase Ⅰ Arcus Biosciences Solid tumours, Hematological cancer Details
BMS-986207 (Bristol-Myers Squibb) BMS-986207 Phase Ⅱ Bristol-Myers Squibb, Ono Pharmaceutical Solid tumours Details
MK-7684 MK-7684; MK7684 Phase Ⅰ Merck Sharp & Dohme Solid tumours Details

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