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| ID | Components | Size |
| EP164-C01 | High-bind Plate | 1plate |
| EP164-C02 | Human GFRAL | 10 μg |
| EP164-C03 | Biotinylated Human GDF15 | 5μg |
| EP164-C04 | Anti-GDF15 Neutralizing Antibody | 10μg |
| EP164-C05 | Streptavidin-HRP | 5μg |
| EP164-C06 | Coating Buffer | 12mL |
| EP164-C07 | 20xWashing Buffer | 50mL |
| EP164-C08 | Blocking Buffer | 50mL |
| EP164-C09 | Substrate Solution | 12mL |
| EP164-C10 | Stop Solution | 7mL |
This kit is developed for screening for inhibitors of human GDF-15 binding to human GFR alpha-like.
It is for research use only.
Find the expiration date on the outside packaging and do not use reagents past their expiration date.
The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
Your experiment will include 4 simple steps:
a) Coat the plate with human OX40 Ligand.
b) Add your molecule of interest to the tests.
c) Add Biotinylated Human OX40 to bind the coated OX40 Ligand.
d) Add Streptavidin-HRP followed by TMB or other colorimetric HRP substrate.
Finally, the half maximal inhibitory concentration (IC50) of your compound to OX40 : OX40 Ligand binding will be determined by comparing OD readings among different experimental groups.
INHIBITION OF GDF15 [Biotinylated]: GFRAL BINDING BY ANTI-GDF15 NEUTRALIZING ANTIBODY
Serial dilutions of Anti-GDF15 Neutralizing Antibody (Catalog # EP164-C04) (1:1 serial dilution, from 2 μg/mL to 0.000976563μg/mL) was added into GDF15 [Biotinylated]: GFRAL binding reactions. The assay was performed according to the protocol described below. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).
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