Name:Macrophage mannose receptor 1 Target Synonym:Macrophage mannose receptor 1-like protein 1?hMR?Macrophage mannose receptor 1?C-type lectin domain family 13 member D-like?CLEC13DL?MRC1L1?MRC1?Mannose Receptor C-Type 1?Mannose Receptor? C Type 1-Like 1?Human Mannose Receptor?MMR?Mannose Receptor? C Typ
Number of Launched Drugs:0 Number of Drugs in Clinical Trials:0 Lastest Research Phase:Discontinued
CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.