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Tyk2

Brief Information

Name:Tyrosine-protein kinase 2
Target Synonym:EC 2.7.10,EC:2.7.10.2,TYK2,Tyrosine Kinase 2,Non-Receptor Tyrosine-Protein Kinase TYK2,EC 2.7.10.2,IMD35,JTK1,TYK2 Kinase
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
TY2-H5549 Human Human Tyk2 Protein, His Tag (MALS verified)
TY2-H5549-structure
TY2-H5549-sds

Part of Bioactivity data

TY2-H5549-MALS-HPLC
Human Tyk2, His Tag (Cat. No. ) MALS images

The purity of Human Tyk2, His Tag (Cat. No. TY2-H5549) was more than 90% and the molecular weight of this protein is around 27-37 kDa verified by SEC-MALS.

  • Background
    Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Customer Reviews

Synonym Name

Tyk2,tyrosine kinase 2

Background

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-?, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-? and -? and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ABBV-712 ABBV-712 Phase 1 Clinical Abbvie Inc Psoriasis Details
OST-122 OST-122 Phase 2 Clinical Oncostellae Inflammatory Bowel Diseases; Fibrosis; Colitis, Ulcerative; Colorectal Neoplasms Details
Brepocitinib PF-841; PF-6700841; PF-06700841; PF-06700841-15 Phase 2 Clinical Pfizer Inc Alopecia; Alopecia Areata; Kidney Diseases; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Vitiligo; Crohn Disease; Dermatitis, Atopic Details
ICP-332 ICP-332 Phase 1 Clinical InnoCare Pharma Ltd Psoriasis; Dermatitis, Atopic Details
GLPG-3667 GLPG-3667 Phase 1 Clinical Galapagos Psoriasis Details
Ropsacitinib PF-06826647 Phase 2 Clinical Pfizer Pharmaceuticals Ltd (China) Psoriasis; Colitis, Ulcerative; Hidradenitis Suppurativa Details
NDI-034858 NDI-034858 Phase 2 Clinical Nimbus Therapeutics Psoriasis; Plaque psoriasis Details
Deucravacitinib BMS-986165; BMS-986165-01 Phase 3 Clinical Bristol-Myers Squibb Company Lupus Vulgaris; Lupus Erythematosus, Discoid; Inflammatory Bowel Diseases; Kidney Diseases; Autoimmune Diseases; Lupus Erythematosus, Cutaneous; Liver Diseases; Lupus Nephritis; Psoriasis; Lupus Erythematosus, Systemic; Arthritis, Psoriatic; Colitis, Ulcerative; Inflammation; Crohn Disease; Plaque psoriasis Details

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