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Tyk2

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Cat. No. Species Product Description Structure Purity Feature
TY2-H5549 Human Human Tyk2 Protein, His Tag (MALS verified)
TY2-H5549-structure
TY2-H5549-sds

Tyk2 Part of Bioactivity data

TY2-H5549-ELISA
Human Tyk2, His Tag (Cat. No. ) MALS images

The purity of Human Tyk2, His Tag (Cat. No. TY2-H5549) was more than 90% and the molecular weight of this protein is around 27-37 kDa verified by SEC-MALS.

  • Background
    Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Tyk2 Molecule Synonym Name

Tyk2,tyrosine kinase 2

Tyk2 Molecule Background

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-?, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-? and -? and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

Tyk2 References

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