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Your Position: Home > Tyk2

Tyk2

Brief Information

Name:Tyrosine-protein kinase 2
Target Synonym:EC:2.7.10.2,TYK2,Tyrosine Kinase 2,Non-Receptor Tyrosine-Protein Kinase TYK2,EC 2.7.10.2,IMD35,JTK1,TYK2 Kinase,EC 2.7.10
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Approved
ACRO Quality

Synonym Name

Tyk2,tyrosine kinase 2

Background

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-?, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-? and -? and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

Clinical and Translational Updates

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