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NOTCH1

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Cat. No. Species Product Description Structure Purity Feature
NO1-H5255 Human Human NOTCH1 Protein, Fc Tag
NO1-H5255-structure
NO1-M52H8 Mouse Mouse NOTCH1 Protein, His Tag
NO1-M52H8-structure
NO1-M52H8-sds
NO1-M52H8-elisa_1

NOTCH1 Part of Bioactivity data

NO1-M52H8-MALS-HPLC
Mouse NOTCH1, His TagMouse NOTCH1, His Tag (Cat. No. NO1-M52H8) ELISA bioactivity

Immobilized Human DLL4, Fc Tag (Cat. No. DL4-H5259) at 5 μg/mL (100 μL/well) can bind Mouse NOTCH1, His Tag (Cat. No. NO1-M52H8) with a linear range of 0.02-0.313 μg/mL (QC tested).

NOTCH1 Molecule Synonym Name

NOTCH1,Notch 1,hN1,TAN1

NOTCH1 Molecule Background

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also  interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1 References

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