Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > NOTCH1

NOTCH1

Brief Information

Name:Neurogenic locus notch homolog protein 1
Target Synonym:Notch Receptor 1,EC 2.1.2.11,Translocation-associated notch protein TAN-1,NEXT,NICD,hN1,NOTCH1,Notch 1,TAN1,Notch (Drosophila) Homolog 1 (Translocation-Associated),Notch Homolog 1, Translocation-Associated (Drosophila),Notch Homolog 1, Translocation-Associated,AOVD1,AOS5,Receptor, Notch1,EC 3.4.21.68,Neurogenic locus notch homolog protein 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Pending

Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
NO1-H5255 Human Human NOTCH1 Protein, Fc Tag (MALS verified)
NO1-H5255-structure
NO1-H5255-sds
NO1-H5255-elisa_1
NO1-H5255-elisa_2
NO1-M52H8 Mouse Mouse NOTCH1 Protein, His Tag
NO1-M52H8-structure
NO1-M52H8-sds
NO1-M52H8-elisa_1

Part of Bioactivity data

NO1-H5255-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Jagged 1, His Tag (Cat. No. JA1-H52H9) immobilized on CM5 Chip can bind Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) with an affinity constant of 5.13 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

NO1-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 67.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

NOTCH1,Notch 1,hN1,TAN1

Background

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also  interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message