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NOTCH1

Brief Information

Name:Neurogenic locus notch homolog protein 1
Target Synonym:EC 2.1.2.11,Notch Receptor 1,NOTCH1,Notch 1,TAN1,Notch (Drosophila) Homolog 1 (Translocation-Associated),Notch Homolog 1, Translocation-Associated (Drosophila),Notch Homolog 1, Translocation-Associated,AOVD1,AOS5,Receptor, Notch1,Translocation-associated
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Pending

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
NO1-H5255 Human Human NOTCH1 Protein, Fc Tag (MALS verified)
NO1-H5255-structure
NO1-H5255-sds
NO1-H5255-elisa_1
NO1-H5255-elisa_2
NO1-M52H8 Mouse Mouse NOTCH1 Protein, His Tag
NO1-M52H8-structure
NO1-M52H8-sds
NO1-M52H8-elisa_1

Part of Bioactivity data

NO1-H5255-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Jagged 1, His Tag (Cat. No. JA1-H52H9) immobilized on CM5 Chip can bind Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) with an affinity constant of 5.13 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

NO1-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 67.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

NOTCH1,Notch 1,hN1,TAN1

Background

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also  interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

Clinical and Translational Updates

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