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NOTCH3

Brief Information

Name:Neurogenic locus notch homolog protein 3
Target Synonym:Notch Receptor 3,Notch 3,NOTCH3,Notch (Drosophila) Homolog 3,Notch Homolog 3 (Drosophila),Notch Homolog 3,CADASIL1,CADASIL,CASIL,IMF2,Receptor, Notch3,Neurogenic Locus Notch Homolog Protein 3,LMNS
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
NO3-H5255 Human Human NOTCH3 Protein, Fc Tag
NO3-H5255-structure
NO3-H5255-sds
NO3-H5255-elisa_1

Part of Bioactivity data

NO3-H5255-MALS-HPLC
Human NOTCH3, Fc TagHuman NOTCH3, Fc Tag (Cat. No. NO3-H5255) ELISA bioactivity

Immobilized Human NOTCH3, Fc Tag (Cat. No. NO3-H5255) at 1 μg/mL (100 μL/well) can bind Bispecific Antibody (NOTCH2 × NOTCH3) with a linear range of 2-20 ng/mL (QC tested).

Synonym Name

Notch-3,NOTCH3

Background

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Clinical and Translational Updates

    Clinical Drug Information

    Name Research Code Research Phase Company Indications Clinical Trials
    Tarextumab OMP-59R5 Phase 2 Clinical Oncomed Pharmaceuticals Solid tumours; Pancreatic Neoplasms; Small Cell Lung Carcinoma Details

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