NOTCH3 Overview
Molecule Name
Neurogenic locus notch homolog protein 3
Synonyms
Notch-3,NOTCH3
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs0
Highest Development StagePreclinical
Target Synonym
Neurogenic Locus Notch Homolog Protein 3，LMNS，Notch 3，NOTCH3，Notch (Drosophila) Homolog 3，Notch Homolog 3 (Drosophila)，Notch Homolog 3，CADASIL1，CADASIL，CASIL，IMF2，Receptor， Notch3，Notch Receptor 3
Background
Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs
NOTCH3 Product List
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