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Your Position: Home > NOTCH3

NOTCH3

NOTCH3 Protein Product ListCompare or Buy

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Cat. No.	Species	Product Description	Structure	Purity	Feature
NO3-H5255	Human	Human NOTCH3 Protein, Fc Tag

NOTCH3 Part of Bioactivity data

NO3-H5255-MALS-HPLC

Human NOTCH3, Fc TagHuman NOTCH3, Fc Tag (Cat. No. NO3-H5255) ELISA bioactivity

Immobilized Human NOTCH3, Fc Tag (Cat. No. NO3-H5255) at 1 μg/mL (100 μL/well) can bind Bispecific Antibody (NOTCH2 × NOTCH3) with a linear range of 2-20 ng/mL (QC tested).

Protocol

NOTCH3 Molecule Synonym Name

Notch-3,NOTCH3

NOTCH3 Molecule Background

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs