NOTCH3 Protein - ACROBiosystems

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NOTCH3

Brief Information

Name:Neurogenic locus notch homolog protein 3
Target Synonym:Notch Receptor 3,Notch 3,NOTCH3,Notch (Drosophila) Homolog 3,Notch Homolog 3 (Drosophila),Notch Homolog 3,CADASIL1,CADASIL,CASIL,IMF2,Receptor, Notch3,Neurogenic Locus Notch Homolog Protein 3,LMNS

Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical


NO3-H5255	Human	Human NOTCH3 Protein, Fc Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

NO3-H5255

Human

Human NOTCH3 Protein, Fc Tag

Part of Bioactivity data

NO3-H5255-MALS-HPLC

Human NOTCH3, Fc TagHuman NOTCH3, Fc Tag (Cat. No. NO3-H5255) ELISA bioactivity

Immobilized Human NOTCH3, Fc Tag (Cat. No. NO3-H5255) at 1 μg/mL (100 μL/well) can bind Bispecific Antibody (NOTCH2 × NOTCH3) with a linear range of 2-20 ng/mL (QC tested).

Protocol

Synonym Name

Notch-3,NOTCH3

Background

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Clinical and Translational Updates

Clinical Drug Information