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SIRP alphaV8

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Cat. No. Species Product Description Structure Purity Feature
SI8-H82W6 Human Biotinylated Human SIRP alphaV8 / CD172a Protein, His,Avitag™
SI8-H82W6-structure
SI8-H82W6-sds
SI8-H82W6-elisa_1

SIRP alphaV8 Part of Bioactivity data

SI8-H82W6-ELISA
Biotinylated Human SIRP alphaV8, His,Avitag™Biotinylated Human SIRP alphaV8, His,Avitag™ (Cat. No. SI8-H82W6) ELISA bioactivity

Immobilized Human CD47, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-H52A5) at 2 μg/mL (100 μL/well) can bind Biotinylated Human SIRP alphaV8, His,Avitag (Cat. No. SI8-H82W6) with a linear range of 0.02-1.25 μg/mL (QC tested).

SIRP alphaV8 Molecule Synonym Name

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

SIRP alphaV8 Molecule Background

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alphaV8 References

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