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Siglec-7

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Part of Bioactivity data

SG7-H82E7-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human Siglec-7, His,Avitag (Cat. No. SG7-H82E7) immobilized on CM5 Chip can bind Neu5Aca2-6GalNAca-PAA-biotin with an affinity constant of 29.2 nM as determined in a SPR assay (Biacore 8K) (QC tested).

SI7-H5257-ELISA
Human Siglec-7, Fc (L118A, G120A, E201A) TagHuman Siglec-7, Fc (L118A, G120A, E201A) Tag (Cat. No. SI7-H5257) ELISA bioactivity

Immobilized Human Siglec-7, Fc (L118A, G120A, E201A) Tag (Cat. No. SI7-H5257) at 5 μg/mL (100 μL/well) can bind Neu5Aca2-6GalNAca-PAA-biotin with a linear range of 0.02-0.313 ng/mL (QC tested).

Synonym Name

CDw328, D-siglec, A79 membrane protein, p75,Adhesion inhibitory receptor molecule 1, AIRM-1

Background

Siglec-7 is a member of the human CD33‐related Siglec receptor. The extracellular region of Siglec‐7 is characterized by an N‐terminal V‐set Ig domain that can bind sialic acid and two C2‐set Ig domains. The cytoplasmic tail of Siglec‐7 has one immune‐receptor tyrosine‐based inhibitory motif (ITIM) and one ITIM‐like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells.

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