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Coagulation Factor III

Brief Information

Name:Tissue factor
Target Synonym:CD142,Coagulation Factor III,Tissue Factor,Thromboplastin,Coagulation Factor III (Thromboplastin, Tissue Factor),Coagulation Factor III, Tissue Factor,F3,TFA,CD142 Antigen,TF
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:NDA/BLA

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Part of Bioactivity data


Anti-TF mAb immobilized on CM5 Chip can bind Human Tissue Factor, Fc Tag (Cat. No. TF3-H5253) with an affinity constant of 2.38 nM as determined in SPR assay (Biacore T200) (Routinely tested).


Anti-TF mAb immobilized on CM5 Chip via anti-human IgG Fc antibody can bind Human Tissue Factor, His Tag (Cat. No. TF3-H52H5) with an affinity constant of 1.52 nM as determined in SPR assay (Biacore T200) (Routinely tested).

Synonym Name

Coagulation Factor III,Tissue Factor,TF,F3,CD142


Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ALT-836 cH-36; ALT-836; TNX-832 Phase 2 Clinical Sunol Molecular Corp Solid tumours; Inflammatory Bowel Diseases; Sepsis; Respiratory Distress Syndrome, Adult; Acute Lung Injury; Thrombosis Details
hI-con1 ICON-1; hI-con1 Phase 2 Clinical Yale University Choroid Neoplasms; Uveal melanoma; Wet Macular Degeneration; Macular Degeneration; Choroidal Neovascularization Details
MRG004A MRG004A Phase 2 Clinical Shanghai Miracogen Inc Solid tumours Details

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