IL-7 R alpha & TSLP R Protein

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IL-7 R alpha & TSLP R

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit

Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical


ILR-H525x	Human	Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag
ILR-H5255	Human	Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

Cat. No.

Species

Product Description

Structure

Purity

Feature

ILR-H525x

Human

Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag

ILR-H5255

Human

Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

Part of Bioactivity data

ILR-H525x-BLI

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H525x) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 1.16 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

ILR-H5255-BLI

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 134 pM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

Background

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Clinical and Translational Updates

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
PF-06342674	RN-168; PF-6342674; PF-06342674		Pfizer Inc		Details
ASP-9801	ASP-9801	Phase 1 Clinical	Astellas Pharma Inc	Solid tumours	Details
Efineptakin alfa	NT-I7; GX-I7; TJ-107	Phase 2 Clinical	Genexine Inc	Pancreatic Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Laryngeal Neoplasms; Carcinoma, Squamous Cell; Glioma; Oropharyngeal Neoplasms; Lymphopenia; Colorectal Neoplasms; Leukopenia; Breast Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Hypopharyngeal Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Glioblastoma; Coronavirus Disease 2019 (COVID-19); Carcinoma, Merkel Cell; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours	Details
Lusvertikimab	OSE-127; S-95011	Phase 2 Clinical	Effimune	Sjogren's Syndrome; Colitis, Ulcerative	Details
Interleukin-7 (Revimmune SAS)	rhIL-7; CYT-107; CYT-99-007	Phase 2 Clinical	Cytheris	HIV Infections; Kidney Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Shock, Septic; Hepatitis B, Chronic; Coronavirus Disease 2019 (COVID-19); Sepsis; Mycobacterium Infections, Nontuberculous; Myeloproliferative Disorders; Breast Neoplasms; Lymphopenia; Hepatitis C; Leukemia, Myeloid, Acute; Melanoma	Details
MDK-703	MDK-703	Phase 1 Clinical			Details

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