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Your Position: Home > IL-7 R alpha & TSLP R

IL-7 R alpha & TSLP R

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ILR-H525x Human Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag
ILR-H525x-structure
ILR-H525x-sds
ILR-H5255 Human Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
ILR-H5255-structure
ILR-H5255-sds

Part of Bioactivity data

ILR-H525x-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H525x) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 1.16 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILR-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 134 pM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

Background

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PF-06342674 RN-168; PF-6342674; PF-06342674 Pfizer Inc Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours Details
Efineptakin alfa NT-I7; GX-I7; TJ-107 Phase 2 Clinical Genexine Inc Pancreatic Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Laryngeal Neoplasms; Carcinoma, Squamous Cell; Glioma; Oropharyngeal Neoplasms; Lymphopenia; Colorectal Neoplasms; Leukopenia; Breast Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Hypopharyngeal Neoplasms; Small Cell Lung Carcinoma; Papillomavirus Infections; Glioblastoma; Coronavirus Disease 2019 (COVID-19); Carcinoma, Merkel Cell; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours Details
Lusvertikimab OSE-127; S-95011 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris HIV Infections; Kidney Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Shock, Septic; Hepatitis B, Chronic; Coronavirus Disease 2019 (COVID-19); Sepsis; Mycobacterium Infections, Nontuberculous; Myeloproliferative Disorders; Breast Neoplasms; Lymphopenia; Hepatitis C; Leukemia, Myeloid, Acute; Melanoma Details
MDK-703 MDK-703 Phase 1 Clinical Details

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