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Your Position: Home > IL-7 R alpha & TSLP R

IL-7 R alpha & TSLP R

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CHEK-ATF045-Cell-based assay
 IL-7 R alpha & TSLP R FACS

Co-expression analysis of human TSLP R and IL-7 R alpha on Human TSLP R (Luc) HEK293 Reporter Cell by FACS.
Cell surface staining was performed on Human TSLP R (Luc) HEK293 Reporter Cell or negative control cell using PE-labeled anti-TSLP R antibody and FITC-labeled anti-IL-7 R alpha antibody.

 IL-7 R alpha & TSLP R BLI

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H525x) on Protein A Biosensor, can bind Human TSLP Protein, His Tag, premium grade (Cat. No. TSP-H52Hb) with an affinity constant of 1.16 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

 IL-7 R alpha & TSLP R BLI

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) on Protein A Biosensor, can bind Human TSLP Protein, His Tag, premium grade (Cat. No. TSP-H52Hb) with an affinity constant of 134 pM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2


TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris Urinary Bladder Neoplasms; Catheter-Related Infections; Neuroectodermal Tumors, Primitive, Peripheral; Melanoma; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Urologic Neoplasms; Ureteral Neoplasms; Hepatitis C; Lymphopenia; Urethral Neoplasms; Prostatic Neoplasms; Sarcoma; Neuroblastoma; Shock, Septic; Prostatic Neoplasms, Castration-Resistant; Carcinoma, Transitional Cell; Sepsis; Myeloproliferative Disorders; Myelodysplastic Syndromes; Mycobacterium Infections, Nontuberculous; Coronavirus Disease 2019 (COVID-19); Carcinoma, Renal Cell; Hepatitis B, Chronic; Rhabdoid Tumor; Leukemia, Myelogenous, Chronic; Kidney Neoplasms; HIV Infections Details
Lusvertikimab OSE-127; S-95011; Effi-7; OSE-217 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
MDK-703 MDK-703 Phase 2 Clinical Medikine Inc Solid tumours Details
Efineptakin alfa TJ-107; GX-I7; NT-I7 Phase 2 Clinical Genexine Inc Breast Neoplasms; Sarcoma, Kaposi; Melanoma; Carcinoma, Non-Small-Cell Lung; Glioma; Laryngeal Neoplasms; Leukoencephalopathy, Progressive Multifocal; Carcinoma, Squamous Cell; Gliosarcoma; Astrocytoma; Oropharyngeal Neoplasms; Colorectal Neoplasms; Lymphopenia; Solid tumours; Urinary Bladder Neoplasms; Hypopharyngeal Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Triple Negative Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Esophageal Neoplasms; Carcinoma, Merkel Cell; Squamous Cell Carcinoma of Head and Neck; Ovarian Neoplasms; HIV Infections Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
PF-06342674 RN-168; PF-6342674; PF-06342674; ZB-168 Phase 1 Clinical Pfizer Inc Diabetes Mellitus, Type 1; Multiple Sclerosis Details
Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) Phase 1 Clinical Chulalongkorn University, King Chulalongkorn Memorial Hospital Brain Neoplasms; Diffuse Intrinsic Pontine Glioma Details
GSK-3888130-B GSK-3888130-B; GSK3888130B Phase 1 Clinical Glaxosmithkline Plc Multiple Sclerosis Details
BNT-152 BNT-152 Phase 1 Clinical Biontech Se Solid tumours Details

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