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Your Position: Home > IL-7 R alpha & TSLP R

IL-7 R alpha & TSLP R

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,CDw127,IL-7RA,IL-7 receptor subunit alpha,IL7R,Interleukin 7 Receptor,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Isoform H5-6,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subun
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ILR-H5255 Human Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
ILR-H5255-structure
ILR-H5255-sds
ILR-H5255-elisa_1

Part of Bioactivity data

ILR-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 134 pM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILR-H5255-MALS-HPLC
Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ) MALS images

The purity of Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) was more than 85% and the molecular weight of this protein is around 125-140 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc TagHuman IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) ELISA bioactivity

Immobilized Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) at 5 μg/mL (100 μL/well) can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with a linear range of 0.4-3 ng/mL (QC tested).

IL-7 R alpha & TSLP R Molecule Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8/CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

IL-7 R alpha & TSLP R Molecule Background

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

IL-7 R alpha & TSLP R References

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GSK-2618960 GSK-2618960 Phase 2 Clinical Glaxosmithkline Plc Multiple Sclerosis, Relapsing-Remitting; Autoimmune Diseases; Sjogren's Syndrome Details
BNT-152 BNT-152 Phase 1 Clinical Biontech Se Solid tumours Details
OSE-127 OSE-127; S-95011 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative; Inflammation Details
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris Mycobacterium Infections, Nontuberculous; Melanoma; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Hepatitis C; Lymphopenia; Prostatic Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; HIV Infections; Myeloproliferative Disorders; Coronavirus Disease 2019 (COVID-19); Sepsis; Hepatitis B, Chronic; Shock, Septic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Kidney Neoplasms Details
Efineptakin alfa (Genexine/NeoImmuneTech) GX-I7; TJ-107; NT-I7 Phase 2 Clinical Genexine Inc Solid tumours; Carcinoma, Merkel Cell; Glioblastoma; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Coronavirus Disease 2019 (COVID-19); Papillomavirus Infections; Brain Neoplasms; Colorectal Neoplasms; Cervical Intraepithelial Neoplasia; Carcinoma, Squamous Cell; Glioma; Carcinoma, Non-Small-Cell Lung; Melanoma Details

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