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Your Position: Home > IL-7 R alpha & TSLP R

IL-7 R alpha & TSLP R

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
EP-129 Human TSLP[Biotinylated]:IL-7Rα & TSLP R Inhibitor Screening ELISA Kit
ILR-H525x Human Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag
ILR-H525x-structure
ILR-H525x-sds
CHEK-ATF045 Human Human TSLP R (Luc) HEK293 Reporter Cell
ILR-H5255 Human Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
ILR-H5255-structure
ILR-H5255-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATF045-Cell-based assay
IL-7 R alpha & TSLP R FACS

Co-expression analysis of human TSLP R and IL-7 R alpha on Human TSLP R (Luc) HEK293 Reporter Cell by FACS.
Cell surface staining was performed on Human TSLP R (Luc) HEK293 Reporter Cell or negative control cell using PE-labeled anti-TSLP R antibody and FITC-labeled anti-IL-7 R alpha antibody.

Protocol
ILR-H525x-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H525x) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 1.16 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
ILR-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) on Protein A Biosensor, can bind Human TSLP, His Tag (Cat. No. TSP-H52Hb) with an affinity constant of 134 pM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

Background

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris Urinary Bladder Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Melanoma; Catheter-Related Infections; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Hepatitis C; Ureteral Neoplasms; Urologic Neoplasms; Lymphopenia; Neuroblastoma; Sarcoma; Urethral Neoplasms; Prostatic Neoplasms; Leukemia, Myelogenous, Chronic; Carcinoma, Transitional Cell; Coronavirus Disease 2019 (COVID-19); Mycobacterium Infections, Nontuberculous; Sepsis; Myeloproliferative Disorders; Myelodysplastic Syndromes; Hepatitis B, Chronic; Carcinoma, Renal Cell; Rhabdoid Tumor; Shock, Septic; Kidney Neoplasms; HIV Infections Details
BNT-152 BNT-152 Phase 1 Clinical Biontech Se Solid tumours Details
Lusvertikimab OSE-127; S-95011 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
Efineptakin alfa NT-I7; GX-I7; TJ-107 Phase 2 Clinical Genexine Inc Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Sarcoma, Kaposi; Carcinoma, Squamous Cell; Leukoencephalopathy, Progressive Multifocal; Lymphopenia; Colorectal Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; Pancreatic Neoplasms; HIV Infections; Small Cell Lung Carcinoma; Coronavirus Disease 2019 (COVID-19); Papillomavirus Infections; Glioblastoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Esophageal Neoplasms; Solid tumours; Ovarian Neoplasms Details
MDK-703 MDK-703 Phase 2 Clinical Medikine Inc Solid tumours Details

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