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Your Position: Home > IL-2 R beta & IL-2 R alpha & IL-2 R gamma

IL-2 R beta & IL-2 R alpha & IL-2 R gamma

Brief Information

Name:Interleukin-2
Target Synonym:T-cell growth factor,IL2,Interleukin 2,T Cell Growth Factor,Aldesleukin,IL-2,TCGF,Involved In Regulation Of T-Cell Clonal Expansion,Interleukin-2,Lymphokine
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Approved

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Part of Bioactivity data

ILG-H52W9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-2RB&IL-2RA&IL-2RG, His Tag&Twin Strep Tag (Cat. No. ILG-H52W9) captured on CM5 chip via anti-His antibody can bind Human IL-2, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 56.9 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

ILG-H82W9-SPR
 IL-2 R beta & IL-2 R alpha & IL-2 R gamma SPR

Biotinylated Human IL-2RB&IL-2RA&IL-2RG, His,Avitag&Twin Strep Tag (Cat. No. ILG-H82W9) captured on Biotin CAP-Series S Sensor Chip can bind Human IL-2 Protein, Tag Free (Cat. No. IL2-H4113) with an affinity constant of 35.1 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IL-2 R beta & IL-2 R alpha & IL-2 R gamma Molecule Synonym Name

IL-2 R beta & IL-2 R alpha & IL-2 R gamma

IL-2 R beta & IL-2 R alpha & IL-2 R gamma Molecule Background

Both Interleukin-2 receptor subunit beta and Interleukin-2 receptor subunit gamma are receptor for interleukin-2. Common subunit for the receptors for a variety of interleukins. Interacts with SHB upon interleukin stimulation. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

IL-2 R beta & IL-2 R alpha & IL-2 R gamma References

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thalidomide NSC-66847; NSC-527179; K-17; VP-02 Approved Celgene Corp Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled Japan Leprosy, Lepromatous Fujimoto Pharmaceutical 1982-01-01 Waldenstrom Macroglobulinemia; Sarcoma; Prostatic Neoplasms; Arachnoiditis; Cholangitis, Sclerosing; Gastrointestinal Hemorrhage; Osteosarcoma; Pancreatitis, Chronic; Retinoblastoma; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Prostatitis; Colitis, Ulcerative; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Erythema Nodosum; Leprosy, Lepromatous; Endometrial Neoplasms; Appendiceal Neoplasms; Pelvic Pain; Angiodysplasia; Glioma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular; Amyotrophic Lateral Sclerosis; Vascular Malformations; Crohn Disease; Precancerous Conditions; Mycobacterium avium-intracellulare Infection; Idiopathic Pulmonary Fibrosis; Leukemia; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Liver Neoplasms; Cough; Telangiectasia, Hereditary Hemorrhagic; Mycobacterium Infections; Rhabdomyosarcoma; Arteriovenous Malformations; Inflammatory Bowel Diseases; Stomatitis, Aphthous; Gastric Antral Vascular Ectasia; Spondylitis, Ankylosing; Myelodysplastic Syndromes; HIV Infections; Coronavirus Dise Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Interleukin-2 gene therapy (St Jude Children's Research Hospital) Phase 1 Clinical St. Jude Children'S Research Hospital, National Cancer Institute Neuroblastoma Details
T20K T-20K Phase 1 Clinical Cyxone Multiple Sclerosis Details
ITI-1000 ITI-1000 Phase 2 Clinical Immunomic Therapeutics Glioblastoma Details
RG-6279 RG-6279 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours Details
S-95007 S-95007 Phase 2 Clinical Laboratoires Servier Immune System Diseases; Inflammation Details
SAR-444336 SAR-444336 Phase 1 Clinical Sanofi Inflammation Details
LMBP2-specific TCR-T cell therapy (TCRCure Biopharma) Phase 2 Clinical Tcrcure Biopharma Ltd Nasopharyngeal Carcinoma Details
SHR-1916 SHR-1916 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Solid tumours Details
ALT-801(Altor BioScience) 264scTCR/IL-2 Altor Bioscience Details
NNC-0361-0041 NNC0361-0041; NNC-0361-0041 Phase 1 Clinical Novo Nordisk A/S Diabetes Mellitus, Type 1 Details
AU-007 BD-8; AU-007; BDG-8 Biolojic Design Inc Neoplasms Details
XTX-202 XTX-202 Details
TG-4010 VV-MUC-IL2; TG-4010 Transgene Details
HBAI-20 HBAI-20; HBAI-20-CyTuVax Cytuvax Details
PM-1016 PM1016; TILT-123 Phase 2 Clinical Tilt Biotherapeutics Ltd Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Melanoma Details
Bifikafusp alfa L19-IL-2 Phase 3 Clinical Philogen Solid tumours; Carcinoma, Basal Cell; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Squamous Cell; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
STK-012 STK-012 Phase 1 Clinical Synthekine Inc Solid tumours; Ovarian Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Microsatellite instability-high cancer; Melanoma; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Darleukin/fibromun L19-IL-2/ L19-TNF-α Phase 3 Clinical Philogen Carcinoma, Merkel Cell; Basal Cell Nevus Syndrome; Melanoma; Sarcoma, Kaposi Details
AVB-001 AVB-001 Phase 1 Clinical Avenge Bio Inc Ovarian Neoplasms Details

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