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Plexin B2

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Cat. No. Species Product Description Structure Purity Feature
PL2-H52H3 Human Human Plexin B2 Protein, His Tag
PL2-H52H3-structure
PL2-H52H3-sds
PL2-H52H3-elisa_1

Part of Bioactivity data

PL2-H52H3-SPR
Human Plexin B2, His TagHuman Plexin B2, His Tag (Cat. No. PL2-H52H3) ELISA bioactivity

Immobilized Human Plexin B2, His Tag (Cat. No. PL2-H52H3) at 5 μg/mL (100 μL/well) can bind Human SEMA4D, Fc Tag (Cat. No. CD0-H5257) with a linear range of 0.039-1.25 μg/mL (QC tested).

Synonym Name

Plexin B2,PLXNB2,KIAA0315,MM1,Plexin-B2

Background

Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.

Clinical and Translational Updates

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