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Your Position: Home > Latent GDF-2

Latent GDF-2

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Cat. No. Species Product Description Structure Purity Feature
GD2-H52H3 Human Human Latent GDF-2 / BMP-9 Protein, His Tag (MALS verified)
GD2-H52H3-structure
GD2-H52H3-sds
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Part of Bioactivity data

GD2-H52H3-SPR
Latent GDF-2 MALS images

The purity of Human Latent GDF-2, His Tag (Cat. No. GD2-H52H3) is more than 90% and the molecular weight of this protein is around 80-95 kDa verified by SEC-MALS.

Synonym Name

Latent GDF-2,Latent GDF2,Latent BMP-9,Latent BMP9

Background

Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.

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